ArticleFrontiers in pharmacology2026
Mechanism of Icariin induces mitochondrial-mediated apoptosis by Wnt/β-catenin signaling pathway in colorectal cancer.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To evaluate the effect of Icariin (ICA) on AOM/DSS-induced colorectal cancer (CRC) in mice as well as CRC cells, and to explore the underlying molecular mechanism. Methods: The therapeutic efficacy of ICA against AOM/DSS-induced CRC was evaluated by detecting tumor growth and pathological alterations. Biomarkers related to Wnt/β-catenin and mitochondrial apoptosis were tested, and cell experiments were performed to validate the regulatory correlation between ICA and the Wnt/β-catenin pathway in CRC cells. Results: ICA significantly reduced tumor number, size and ameliorated pathological damage in AOM/DSS-induced mice by regulating the mitochondrial-mediated apoptosis of colon tissue. ICA's regulation of mitochondrial-mediated apoptosis was confirmed to involve the Wnt/β-catenin signaling pathway. Conclusion: The study demonstrated that ICA promoted mitochondrial-mediated apoptosis by regulating the Wnt/β-catenin signaling pathway, suggesting that ICA could serve as a potential treatment for CRC.
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