ArticleFrontiers in microbiology2026
Intestinal microbiota alteration in women with adenomyosis and clinical characteristics correlation.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Adenomyosis is an enigmatic disease with estrogen dependence, and the exact pathogenic mechanisms remain confusing. Limited evidence points out the presence of gut flora changes in adenomyosis. However, evidence on how adenomyosis and gut microbiota crosstalk remains insufficient. Methods: This study included 30 female diagnosed with adenomyosis and 28 healthy control participants. Fecal samples were collected from all subjects prior to the initiation of pharmacological treatment. The 16S rRNA gene sequencing technique was utilized to analyze the fecal samples, with the objective of characterizing the composition and potential functional profile of the gut microbiota, as well as examining the correlations between the gut microbiota and disease-related clinical variables. Results: Compared with healthy controls, patients with adenomyosis showed a distinct gut microbial community composition. The adenomyosis group was significantly enriched in Conclusion: A potential association exists between adenomyosis and the intestinal microbiome. Clinical characteristics of adenomyosis are related to the intestinal microbiota. These findings offer microbiota-derived evidence and new perspectives on the pathophysiology of adenomyosis.
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