SynthesisFrontiers in endocrinology2026
Effects of fasting on thyroid hormone profiles: a systematic review and meta-analysis of TSH, FT3, FT4, and total T3 responses.
Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Fasting induces coordinated metabolic and endocrine adaptations, yet its effects on thyroid hormone dynamics remain incompletely characterized. This systematic review and meta-analysis aimed to evaluate the effects of fasting on thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and total triiodothyronine (total T3). Methods: PubMed, Web of Science, and Scopus were searched for peer-reviewed original research articles published in English between January 2000 and June 2026. Human studies examining fasting interventions lasting ≥ 24 h and reporting pre-post thyroid hormone data in adults were included. Standardized mean changes were calculated as Hedges' Results: Fifteen studies were included in the systematic review. Fasting was associated with significant reductions in FT3 ( Conclusions: Fasting produces a biomarker-specific thyroid response characterized by pronounced reductions in FT3 and total T3, a moderate decrease in TSH, and relative stability of FT4. This pattern is more consistent with altered peripheral thyroid hormone metabolism and reduced T4-to-T3 conversion than with a uniform suppression of thyroid hormone production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.