Evidence map›Paper›PMID 42625502›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Interpreting p-tau217 on the ward: frailty and plasma biomarkers in acutely admitted older adults.

Jonas Goll, Ieva Martinaityte, Bjørn-Eivind Kirsebom, Dag Seeger Halvorsen, Fernando Gonzalez-Ortiz, Henrik Zetterberg, Tormod Fladby, Mona Dixon Gundersen

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jonas GollDepartment of Geriatrics, University Hospital of North Norway, Tromsø, Norway.
Ieva MartinaityteDepartment of Geriatrics, University Hospital of North Norway, Tromsø, Norway.
Bjørn-Eivind KirsebomDepartment of Neurology, University Hospital of North Norway, Tromsø, Norway.
Dag Seeger HalvorsenDepartment of Geriatrics, University Hospital of North Norway, Tromsø, Norway.
Fernando Gonzalez-OrtizDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Tormod FladbyDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.
Mona Dixon GundersenDepartment of Geriatrics, University Hospital of North Norway, Tromsø, Norway.

Funding

European Union's Horizon Europe research and innovation programme 101053962Northern Norway Regional Health Authority HNF1713-24Swedish Research Council 2019-02397Swedish Research Council 2022-01018Swedish Research Council 2023-00356Swedish State Support for Clinical Research #ALFGBG-71320University Hospital of North Norway
6 · The paper itself

Abstract

introductionOlder adults living with frailty are prone to adverse events upon acute hospitalization. Frailty biomarkers aiding early identification are lacking. This study explores frailty and Alzheimer's disease (AD)-related biomarkers.

methodsParticipants were recruited from the Norfrail study (n = 178) and from the Norwegian Dementia Disease Initiative (n = 105). Linear regression was used to analyze associations between frailty and the plasma biomarkers phosphorylated tau-217 (p-tau217), neurofilament light chain (NfL), brain-derived tau, ubiquitin carboxyl-terminal hydrolase L1, and glial fibrillary acidic protein in older adults admitted acutely to hospital.

resultsNo significant association was found between p-tau217 and frailty. Estimated glomerular filtration rate (eGFR) explained 27% of the variance of plasma p-tau217 (p < 0.001). NfL was the only biomarker significantly associated with frailty (p < 0.01). DISCUSSION: Except for NfL, plasma biomarkers were independent of frailty. Substantial p-tau217 variability was explained by eGFR. Clinicians need to consider renal function when interpreting p-tau217 in unselected populations.

Indexed as

Frailtytau ProteinsAgedAged, 80 and overAlzheimer DiseaseBiomarkersFemaleFrail ElderlyGlial Fibrillary Acidic ProteinGlomerular Filtration RateHospitalizationHumansMaleNeurofilament ProteinsNorwayPhosphorylationBiomarkersGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinstau ProteinsagingAlzheimer's diseaseblood biomarkersclinical heterogeneitycognitive declinefrailtykidney functionNfLpathophysiologyplasmap‐tau217

Identifiers

PMID42625502
PMCPMC13494674

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