Evidence map›Paper›PMID 42625451›Full record

ArticleJournal of paediatrics and child health2026

Vasopressin Use in Extremely Preterm Infants With Refractory Cardiopulmonary Instability: Physiological Response and Mortality-Associated Factors.

Faisal Alamer, Kamal Ali, Saif Alsaif, Mohanned Alrahili, Mohammed Almahdi, Eman Bazbouz, Rana Almuqati, Saad Alshareedah, Faisal Alsehli, Abdulaziz Homedi

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Article in Journal of paediatrics and child health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Faisal AlamerNeonatal Intensive Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Kamal AliNeonatal Intensive Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-5516-717X
Saif AlsaifNeonatal Intensive Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Mohanned AlrahiliNeonatal Intensive Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Mohammed AlmahdiNeonatal Intensive Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Eman BazbouzNeonatal Intensive Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Rana AlmuqatiNeonatal Intensive Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Saad AlshareedahNeonatal Intensive Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Faisal AlsehliNeonatal Intensive Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Abdulaziz HomediNeonatal Intensive Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the physiological response following vasopressin initiation and identify factors associated with mortality in extremely preterm infants with refractory cardiopulmonary instability. STUDY

designRetrospective cohort study of infants born at less than 29 weeks' gestation who received vasopressin. Physiological responses and mortality were evaluated using multivariate logistic regression and receiver operating characteristic analyses.

resultsThe cohort included 87 infants, of whom 60 (69.0%) died before discharge. Prior to vasopressin initiation, non-survivors had lower pH (7.20 [7.07-7.26] vs. 7.25 [7.21-7.30]; p = 0.009), higher lactate concentrations (5.6 vs. 1.1 mmol/L; p = 0.001), and higher oxygen saturation index (14.7 vs. 12.0; p = 0.022). Following vasopressin initiation, mean blood pressure increased from 29.0 to 39.0 mmHg at 24 h (p < 0.001), while FiO

conclusionVasopressin initiation was associated with improved physiological markers. Mortality was associated more strongly with impaired perfusion and oxygenation severity than with blood pressure alone.

Indexed as

Infant, Extremely PrematureVasoconstrictor AgentsVasopressinsFemaleHumansInfant, NewbornMaleRetrospective StudiesVasoconstrictor AgentsVasopressins

Identifiers

PMID42625451
PMCPMC13671244

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.