Evidence map›Paper›PMID 42625429›Full record

ArticleChemMedChem2026

Reversible Coordination Modes in Piperazine-Based Ru(II)-p-Cymene Acylthiourea Complexes: Modulating DNA Groove Binding for Selective Antimelanoma Activity.

Amir Karim, Xin Wang, Yu-Ting Chu, Rahimeh Eshaghi Malekshah, En-De Shu, Najeeb Ullah, Chien-Chih Chiu, Ching-Ming Chien, Sodio C N Hsu

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Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amir KarimDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-1991-6946
Xin WangDepartment of Applied Chemistry, National Chiayi University, Chiayi, Taiwan.ORCID https://orcid.org/0009-0008-7176-6608
Yu-Ting ChuInternational PhD Program for Science, National Sun Yat-Sen University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-1435-7006
Rahimeh Eshaghi MalekshahDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-1835-2605
En-De ShuDepartment of Applied Chemistry, National Chiayi University, Chiayi, Taiwan.ORCID https://orcid.org/0009-0006-9585-7681
Najeeb UllahDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0009-0000-1416-8224
Chien-Chih ChiuDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0001-7307-2468
Ching-Ming ChienDepartment of Applied Chemistry, National Chiayi University, Chiayi, Taiwan.ORCID https://orcid.org/0000-0002-4922-1571
Sodio C N HsuDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.

Funding

Kaohsiung Medical University KMU-TB115002National Science and Technology Council, Taiwan NSTC 113-2113-M-037-006National Science and Technology Council, Taiwan NSTC 113-2113-M-037-017National Science and Technology Council, Taiwan NSTC 114-2113-M-415-002-MY2NSYSU-KMU Joint Research Project NSYSUKMU 114-P20
6 · The paper itself

Abstract

Acylthiourea ligands, featuring hard (N, O) and soft (S) donor atoms, enable diverse coordination modes in half-sandwich Ru(II)-p-cymene complexes. Herein, we report the synthesis and full characterization of eight half-sandwich Ru(II)-p-cymene complexes, comprising four monodentate (1m-4m) and four bidentate (1b-4b) species prepared under distinct synthetic conditions. The structures of the complexes 1m, 2m, 3m, 3b, and 4b were confirmed by single-crystal X-ray diffraction, while FT-IR, UV-vis, ESI-MS, and

Indexed as

Antineoplastic AgentsCoordination ComplexesCymenesDNAPiperazineRutheniumThioureaBinding SitesCell Line, TumorCell ProliferationCrystallography, X-RayDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity Relationship4-cymeneAntineoplastic AgentsCoordination ComplexesCymenesDNAPiperazineRutheniumThioureaacylthiourea ligandsanticancer activitiescoordination modemolecular dockingRu‐p‐cymene complexes

Identifiers

PMID42625429
PMCPMC13494449

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.