ArticlePain research & management2026
Evolving Trends and Core Contributors: A Bibliometric Update on Liposomal Bupivacaine.
Article in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Evolving Trends and Core Contributors: A Bibliometric Update on Liposomal Bupivacaine.Pain research & management · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeThis study aims to examine the academic output, key research hotspots, collaborative networks, and trends in liposomal bupivacaine research using bibliometric methods. By providing a broad overview, we seek to clarify the knowledge structure and emerging trends in its clinical applications in perioperative analgesia.
methodsWe searched the Web of Science Core Collection database on November 4, 2025, to find relevant articles and reviews. Analytical tools such as CiteSpace and VOSviewer were used to evaluate publication years, countries/regions, institutions, journals, highly cited literature, terms, collaboration networks, and cocitation clusters.
resultsThe dataset comprised 1,069 valid publications from 101 countries/regions, involving 3,256 institutions and 13,736 authors. The annual publication output grew slowly before 2015, increased rapidly after 2016, and reached a peak in 2021. The United States (US) was the leading contributor with 775 publications, followed by China with 155 publications. The Harvard University System and the University of Texas System were identified as central research institutions. Journal of Arthroplasty published the largest number of articles, while Anesthesia and Analgesia recorded the highest average citations per article. Term co-occurrence and burst analyses identified four major research clusters: formulation and pharmacological foundations, safety considerations, procedure-specific analgesia, and emerging regional anesthesia techniques. Recent research hotspots included erector spinae plane block, thoracic surgery, and paravertebral block, indicating a shift toward novel nerve block applications and complex surgical scenarios.
conclusionResearch on liposomal bupivacaine has evolved from formulation development to a clinically oriented field with strong interdisciplinary integration and expanding procedural applications. The US remained the leading contributor to global research and collaboration. These findings provide a structured overview of the evolving evidence base and might help guide future procedure-specific research and perioperative analgesia strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.