ArticleEuropean journal of clinical investigation2026
MicroRNA and Inflammatory Biomarker Signatures Associated With Neurological Outcome After Out-Of-Hospital Cardiac Arrest: The MiRacle Study.
Article in European journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEarly neuroprognostication in Out-of-Hospital Cardiac Arrest (OHCA) remains challenging due to the lack of reliable biomarkers. Circulating microRNAs have emerged as potential indicators of inflammation and brain injury (HIBI). This study aimed to evaluate whether in silico-predicted microRNAs could discriminate neurological outcomes early in OHCA patients.
methodsConsecutive OHCA patients admitted to the Acute Cardiac Care Unit with available cryopreserved blood samples were analysed. Neurological outcome was classified into favourable (Cerebral Performance Category (CPC) 1-2) and unfavourable (CPC 3-5). Blood samples at 0, 24, 72 h after hospital admission were collected. An in silico-derived network of inflammation-HIBI-related microRNA was generated and validated in all patients at the three time-points.
resultsA total of 100 patients were included (59.7 ± 12.5 years, 19% women). 53% had unfavourable neurological outcomes. Eleven candidate microRNAs were identified, showing differential time-dependent expression within 72 h. The earlier and most predictive microRNAs for unfavourable neurological outcome were miR-1-3p (AUC 0.637) and miR-124-3p (AUC 0.606) at 0 h, miR-21-5p (AUC 0.614) and miR-499a-5p (AUC 0.645) at 24 h. The miR-499-5p maintained the best AUC across all time-points. A multiparametric model achieved an AUC of 0.690. A pro-inflammatory environment, characterised by C-Reactive Protein (CRP) and neutrophil-to-lymphocyte ratio, showed distinct temporal expression patterns regarding neurological outcome. Neuroinflammatory miR-let-7a-5p, miR-23a-3p and miR-146a-5p were significantly overexpressed in the unfavourable group and correlated positively with CRP.
conclusionsIn silico derived inflammatory and HIBI-related microRNAs showed time-dependent expression patterns that may distinguish neurological outcomes within 72 h after OHCA.
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