ArticleJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2026
Feline cutaneous mast cell tumor with extensive macrophage-associated cell-in-cell structures.
Article in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
An 8-y-old, castrated male Korean Shorthair cat was presented to a veterinary clinic for evaluation of a cutaneous mass on the left inner thigh. Microscopic examination revealed a poorly circumscribed dermal neoplasm composed of poorly granulated, pleomorphic neoplastic mast cells with frequent cell-in-cell structures. Notably, viable neoplastic mast cells were engulfed by large macrophages, indicating a specific form of the cell-in-cell phenomenon. Immunohistochemistry for c-KIT, IBA1, and cleaved caspase-3 was used to support the diagnosis. To our knowledge, cell-in-cell phenomenon has not been previously described in feline cutaneous mast cell tumors, nor has the clinical outcome of such cases been reported.
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