Evidence map›Paper›PMID 42625225›Full record

ArticleParasites & vectors2026

Blocking Dirofilaria immitis transmission by treatment of heartworm microfilaremic dogs with doxycycline.

John Wilson McCall, Abdelmoneim Mansour, Utami DiCosty, Crystal Fricks, Scott McCall, Ben Carson, Michael Timothy Dzimianski, Charles Thomas Nelson, Andrew R Moorhead

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John Wilson McCallTRS Labs, Inc., Athens, GA, 30607, USA. jwmccall@uga.edu.
Abdelmoneim MansourTRS Labs, Inc., Athens, GA, 30607, USA.
Utami DiCostyTRS Labs, Inc., Athens, GA, 30607, USA.
Crystal FricksTRS Labs, Inc., Athens, GA, 30607, USA.
Scott McCallTRS Labs, Inc., Athens, GA, 30607, USA.
Ben CarsonTRS Labs, Inc., Athens, GA, 30607, USA.
Michael Timothy DzimianskiDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA.
Charles Thomas NelsonAnimal Medical Center, Anniston, AL, 36268, USA.
Andrew R MoorheadDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study was conducted to determine whether heartworm infective larvae (L

methodsA total of 20 heartworm microfilaremic Beagles in a separate study allocated to four groups (n = 5/group) of five dogs were used as blood donors for mosquito infection. These donor dogs in groups 4, 5, and 6 had received doxycycline orally at 5.0, 7.5, or 10.0 mg/kg twice daily (BID) × 14 or 21 days, and ivermectin orally (minimum 6 mcg/kg) on day 0. Group 2 served as the untreated control. To produce infective larvae for each study, two sets of four groups of Aedes aegypti mosquitoes fed on blood from these four groups of dogs on day 14 (study A) or 21 (study B), respectively, and, infective third-stage larvae (L

resultsOverall, 11 of the 12 dogs that had received L

conclusionsTreatment of microfilaremic dogs with doxycycline administered daily at 10.0 or 7.5 mg/kg BID for 14 days and one monthly dose of a heartworm preventive (macrocyclic lactone [ML]) renders the L

Indexed as

Dirofilaria immitisDirofilariasisDog DiseasesDoxycyclineFilaricidesAedesAnimalsDogsFemaleIvermectinLarvaMaleDoxycyclineFilaricidesIvermectinBlocking transmissionDevelopmentDirofilaria immitisDogsDoxycyclineIvermectinMigrationMosquitoes

Identifiers

PMID42625225
PMCPMC13491866

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.