ArticleParasites & vectors2026
Assessing the performance of trūRapid™ FOUR heartworm antigen test for early detection in experimentally infected dogs in comparison to other point-of-care tests.
Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Evaluation of the trūRapidParasites & vectors · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe American Heartworm Society (AHS) recommends diagnosing canine heartworm (HW) infection using both antigen and microfilaria detection tests. Antigen-antibody immune complexes may block antigen detection. Therefore, the AHS recommends immune complex dissociation (ICD) via heat treatment for discordant cases. The trūRapid™ FOUR antigen test kit (Antech Diagnostics) is a novel commercially available point-of-care (POC) device. This study evaluated the performance of trūRapid™ FOUR compared to other commercially available POC tests, namely SNAP
methodsArchival frozen serum samples from six purpose-bred beagles experimentally infected with Dirofilaria immitis were collected weekly for 5.5 months, from week 1 to week 22 post-infection. Sera were tested for the detection of HW antigen, pre- and post-ICD, via heat treatment (103 °C for 10 min in a heat block) using each of the commercial antigen tests. DiroCHEK
resultsHW antigen was not detected in samples collected from week 1 through week 19. In week 20, the trūRapid™ FOUR, SNAP
conclusionsOur findings indicate that trūRapid™ FOUR and other commercially available antigen detection tests can detect HW antigen as early as 5 months post-infection when serum is subjected to heat treatment. The performance of trūRapid™ FOUR is comparable to other widely used commercial antigen kits. Its ease of use and ability to detect HW infection earlier in the course of antigenemia makes it an excellent POC diagnostic tool, allowing for prompt clinical intervention, and increasing patient quality of life.
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