Observational studyBMC oral health2026
The effect of photodynamic therapy on post-endodontic pain in treatments performed by undergraduate students.
Observational study in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07254260 (Photodynamic Therapy), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Photodynamic Therapy (PDT) and Postendodontic Pain
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to investigate whether adjunctive photodynamic therapy (PDT) could reduce postoperative pain following root canal treatment of mandibular posterior teeth performed by undergraduate dental students.
methodsPatients treated in the undergraduate clinic were included if they required endodontic treatment of mandibular posterior teeth and had no systemic contraindications or acute infections. The participants were divided into two groups: conventional final irrigation without activation (CG) and adjunctive PDT application (PDT group). Both groups received 2.5% NaOCl and 17% EDTA during the second visit; in the PDT group, methylene blue was applied and activated with PDT. Postoperative pain was assessed using a numeric rating scale (NRS) at 24, 72 h, and 7 days. Analgesic consumption and the occurrence of flare-ups requiring unscheduled visits were also recorded. Statistical analyses were performed with a significance level of 0.05.
resultsA total of 92 patients were analysed (47 in the PDT group and 45 in the CG). Pain levels decreased significantly over time in both groups (P < 0.05). The PDT group demonstrated significantly lower pain scores at 72 h compared with the control group (P < 0.05). Medication use was lower in the PDT group: three patients required analgesics, and none needed antibiotics, compared with six patients (nine tablets) using analgesics and three receiving antibiotics in the CG.
conclusionWithin the limitations of this retrospective comparative cohort study, adjunctive photodynamic therapy may be a useful adjunct to endodontic treatment in mandibular posterior teeth treated by undergraduate students.
trial registrationThis study was registered with www. CLINICALTRIALS: gov (ClinicalTrials.gov Identifier: NCT07254260) on 14 November 2025 (retrospectively registered).
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