Evidence map›Paper›PMID 42625140›Full record

ArticleBrain and behavior2026

Brain-Behavior Relationships in Children With ADHD: Resting-state EEG Networks Underlying Executive Function and Neurological Soft Signs.

Merve Kuz, Halit Necmi Uçar, Serap Aydın, Fatih Hilmi Çetin, Serhat Türkoğlu

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Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Merve KuzDiamind Mental Academy, Child-Adolescent Psychiatry & Psychotherapy Clinic, Konya, Türkiye.
Halit Necmi UçarDiamind Mental Academy, Child-Adolescent Psychiatry & Psychotherapy Clinic, Konya, Türkiye.
Serap AydınMedical Faculty, Biophysics Department, Hacettepe University, Ankara, Türkiye.
Fatih Hilmi ÇetinDiamind Mental Academy, Child-Adolescent Psychiatry & Psychotherapy Clinic, Konya, Türkiye.
Serhat TürkoğluDepartment of Child and Adolescent Psychiatry, Selçuk University, Konya, Türkiye.

Funding

Selçuk University Scientific Research Projects Coordination Unit 21122034
6 · The paper itself

Abstract

purposeTo investigate sex-stratified brain-behavior relationships between large-scale functional brain network topology and executive-motor profiles in pediatric ADHD, using a multi-dimensional parameter exploration approach.

methodGraph-theoretical connectivity measures were derived from resting-state EEG in 41 medication-naïve children with ADHD (10 girls) and 42 healthy controls (HCs) (10 girls), aged 6-12 years. Sex-specific within- and between-group differences were examined across temporal windows (1-2-4 s), frequency bands, and network densities (10%-30%). Associations between connectivity measures and behavioral/clinical profiles (Stroop, PANESS, Turgay DSM-IV scales) were also assessed.

findingsDirected Transfer Function showed more reliable predictions than phase-sensitive estimators. ADHD-girls showed lower local connectivity, and HC-girls showed higher integration/segregation in within-group gender differences in lower alpha at sparse network densities (10%-15%). Network alterations and meaningful brain-behavioral relationships were limited to upper alpha and beta at denser network configurations (20%-30%) in ADHD-girls. Total gait/station was negatively correlated with integration in HC, positively correlated with hub-to-hub organization in ADHD. The edge-level differences were localized at right centro-temporal locations (FC6-T8) in boys, while the fewer and weaker differences were localized at antero-posterior, occipital-centric connections converging onto AF3 locus in girls.

conclusionThe density-dependent emergence of brain-behavior correlations in girls offers a plausible network-level explanation for the diagnostic camouflage effect reported in females with ADHD. Pediatric ADHD manifests through sex-specific network reconfigurations, a right-hemispheric inhibitory-circuit deficit in boys versus an antero-posterior sensory-gating alteration in girls.

Indexed as

Attention Deficit Disorder with HyperactivityBrainExecutive FunctionNerve NetChildElectroencephalographyFemaleHumansMaleRestADHDbrain networkneurological soft signsresting‐state EEGstroop test battery

Identifiers

PMID42625140
PMCPMC13493694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.