Evidence map›Paper›PMID 42625116›Full record

ArticleMolecular neurobiology2026

Side-Chain Homologs of Δ

Oleh Durydivka, Ondřej Florián, Petr Palivec, Monika Mrňavá, Petra Cihlářová, Martin Kuchař

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Oleh Durydivka *Forensic Laboratory of Biologically Active Substances, Department of Analytical Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague, Czech Republic. oleh.durydivka@vscht.cz.ORCID http://orcid.org/0000-0001-9206-4092
Ondřej Florián *Forensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague, Czech Republic.ORCID http://orcid.org/0009-0004-1572-5589
Petr PalivecForensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague, Czech Republic.ORCID http://orcid.org/0000-0003-3729-8712
Monika MrňaváForensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague, Czech Republic.ORCID http://orcid.org/0009-0002-0030-4218
Petra CihlářováForensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague, Czech Republic.ORCID http://orcid.org/0000-0001-6552-0697
Martin KuchařForensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague, Czech Republic. kuchara@vscht.cz.ORCID http://orcid.org/0000-0002-7616-6352

Funding

Government Office grant "Evaluation of semisynthetic cannabinoids" AA-38-25Specific University Research A1_FPBT_2026_004
6 · The paper itself

Abstract

Minor cannabinoids and semisynthetic cannabis constituents, such as derivatives of tetrahydrocannabinol (THC) and hexahydrocannabinol (HHC), are increasingly encountered in consumer products, yet their signaling profiles at cannabinoid receptors remain incompletely characterized. Here, we describe how structural modifications of THC and HHC, including variations in alkyl side-chain length (C3-C8), double-bond position (Δ

Indexed as

CannabinolDronabinolReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Signal Transductionbeta-ArrestinsHEK293 CellsHumansbeta-ArrestinsCannabinolDronabinolReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2ArrestinsCannabinoid receptorsG protein-coupled receptorsSignal transductionStructure-activity relationshipTetrahydrocannabinol

Identifiers

PMID42625116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.