ReviewMikrochimica acta2026
Raman reporters for SERS/SERRS biosensing and biomedicine: design, applications, and challenges.
Review in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
8 authors.
Funding
Abstract
Surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS) offer molecular fingerprint specificity, high sensitivity, narrow spectral bandwidths, and multiplex readout capability for biosensing and biomedical analysis. In reporter-encoded SERS/SERRS nanotags, Raman reporters are key signal-generating molecules that define spectral identity, context-dependent brightness, stability, multiplexing capacity, and quantitative reliability. However, existing reviews have mainly focused on plasmonic substrates, nanotag architectures, assay formats, imaging applications, or spectral-analysis workflows, whereas reporter molecules themselves have been less systematically discussed as molecular and interfacial design variables. This review provides a focused, reporter-centered synthesis of conventional, aromatic thiol/disulfide, Raman-silent-region, near-infrared-resonant/SERRS, responsive, and library-based reporters. We discuss reporter selection principles, reporter-core interactions, immobilization chemistry, surface coverage and orientation, spectral orthogonality, responsive-reporter metrics, multiplex unmixing, machine-learning-assisted spectral decoding, biomolecular scaffolds, and whole-nanoprobe safety. By integrating molecular design, interfacial stability, quantitative performance evaluation, and translational constraints, this review aims to support rational Raman reporter selection, benchmarking, and application-specific deployment.
Indexed as
Identifiers
42625097What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.