Evidence map›Paper›PMID 42625082›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

AI and neuroimaging in autism spectrum disorder: advances in diagnosis, methodological challenges and future directions.

Kuljeet Singh, Khushi Mogha, Sidi Mohamed Sid'El Moctar

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In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kuljeet SinghDepartment of Computer Science, School of Sciences, Christ University, Bengaluru, 560029, India. kuljeetshan94@gmail.com.ORCID http://orcid.org/0000-0003-2592-8625
Khushi MoghaDepartment of Computer Science, School of Sciences, Christ University, Bengaluru, 560029, India.
Sidi Mohamed Sid'El MoctarUniversité de Technologie de Compiègne, CNRS, BMBI, Compiègne, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutism Spectrum Disorder (ASD) is characterized by challenges in social interaction, communication, and restricted or repetitive behaviors, with motor abnormalities increasingly recognized as potential indicators for early identification.

objectiveThis paper presents a comprehensive review of recent advancements in ASD research, with particular emphasis on neuroimaging, artificial intelligence (AI), and machine learning (ML)-based diagnostic approaches. The review examines global and country-specific prevalence trends, current diagnostic methodologies, and existing therapeutic interventions.

methodsThrough a critical analysis of the literature, including experimental and review studies, key challenges are identified, such as small sample sizes, limited population diversity, heterogeneous imaging protocols, restricted generalizability, and reliance on single-modal datasets. The review further summarizes publicly available ASD datasets and evaluates the strengths and limitations of contemporary AI-driven neuroimaging approaches for ASD diagnosis.

resultsThe contributions of this study include a comprehensive synthesis of neuroimaging and AI-based diagnostic methods, an analysis of available datasets, and a critical evaluation of current methodological challenges and future research directions.

conclusionThe findings highlight the growing potential of AI-driven tools for supporting early ASD diagnosis while emphasizing the need for standardized protocols, external validation, explainable AI, and clinically translatable frameworks. Future research should focus on improving dataset diversity, conducting multicenter clinical validation studies, and integrating adaptive learning methodologies to enhance the reliability and applicability of ASD diagnostic systems. This study contributes to the growing body of multidisciplinary research aimed at advancing early diagnosis, personalized intervention, and evidence-based clinical decision support for individuals with ASD.

Indexed as

Artificial IntelligenceAutism Spectrum DisorderMachine LearningNeuroimagingHumansArtificial intelligenceAutism Spectrum Disorder (ASD)Early diagnosisMachine learningNeuroimaging

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.