Evidence map›Paper›PMID 42625054›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Digital [

Gad Abikhzer, Aubert Roy, Maxime Samson, Nandini Dendukuri, Jean-Paul Makhzoum, Michael A Stein, Marie Hudson, Étienne Rousseau, Pieter H Nienhuis, Kornelis S M Van der Geest and 5 more

Registry-linked trialAbstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05000138 (FDG Digital PET/CT as First Line Investigation for Giant Cell Arteritis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05000138 completednot on this map

FDG Digital PET/CT as First Line Investigation for Giant Cell Arteritis

TypeobservationalSponsorJewish General HospitalRan2022 to 2025Enrolled92ConditionsGiant Cell Arteritis, VasculitisArmsFDG PET/CT
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gad AbikhzerDepartment of Medical Imaging, Jewish General Hospital, Montréal, Canada.
Aubert RoyDepartment of Medical Imaging, Jewish General Hospital, Montréal, Canada. aubert.roy@mail.mcgill.ca.ORCID http://orcid.org/0000-0001-5295-4314
Maxime SamsonDepartment of Internal Medicine and Clinical Immunology, Referral Center for Rare Systemic Autoimmune and Autoinflammatory Diseases, Dijon-Bourgogne University Hospital, University EPE Bourgogne Europe, Dijon, France.
Nandini DendukuriDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Canada.
Jean-Paul MakhzoumDepartment of Medicine, Hôpital du Sacré-Coeur de Montréal, Vasculitis Clinic, University of Montréal, Montréal, Canada.
Michael A SteinDivision of Rheumatology, Department of Medicine, McGill University, Montréal, Canada.
Marie HudsonDivision of Rheumatology, Department of Medicine, McGill University, Montréal, Canada.
Étienne RousseauDepartment of Nuclear Medicine, Centre Hospitalier de l'Université de Sherbrooke, University of Sherbrooke, Sherbrooke, Canada.
Pieter H NienhuisDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Kornelis S M Van der GeestDepartment of Rheumatology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Christian PineauDivision of Rheumatology, Department of Medicine, McGill University, Montréal, Canada.
Patrick LiangDepartment of Rheumatology, Centre hospitalier de l'Université de Sherbrooke, University of Sherbrooke, Sherbrooke, Canada.
Leonard A LevinDepartment of Ophthalmology and Visual Sciences, McGill University, Montréal, Canada.
Riemer H J A SlartDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Jean-Louis AlberiniDepartment of Nuclear Medicine, Université Bourgogne Europe, Centre Georges-François Leclerc, Unicancer, Dijon, France.

Funding

Canadian Rheumatology Association Canadian Initiative for Outcomes in Rheumatology cAre (CIORA) grant
6 · The paper itself

Abstract

purposeDiagnosis of giant cell arteritis (GCA) is challenging and relies mainly on temporal artery biopsy and/or Doppler ultrasound (DUS). Although [

methodsPatients aged ≥ 50 years with suspected GCA based on classical symptoms and inflammatory markers were enrolled. Exclusion criteria included corticosteroid therapy for > 3 days prior to PET/CT or prior history of vasculitis. PET/CT scans were interpreted independently by two blinded readers using standardized visual grading scales; in case of disagreement, a third blinded reader adjudicated. DUS of the temporal and axillary arteries was performed as standard of care. Temporal artery biopsy was performed at the treating physician's discretion. Final clinical diagnosis at 6 months served as reference standard.

resultsOf 92 enrolled subjects, 8 were excluded as they did not undergo DUS. Eighty-four subjects (mean age: 72 years; mean CRP: 70.7 mg/L) were included in the analysis with mean follow-up of 27 months (range 6-74). GCA was diagnosed in 44/84 patients. PET/CT sensitivity increased from 50.0% (95%CI: 34.6-65.4%) to 86.4% (95%CI: 72.7-94.8%) when incorporating C-GCA assessment, with specificity at 100.0% (95%CI: 91.2-100.0%). DUS demonstrated sensitivity 68.2% (95%CI: 52.4-81.4%) and specificity 92.5% (95%CI: 79.6-98.4%).

conclusionDigital [ TRIAL REGISTRATION NUMBER: NCT05000138. Trial registration date: 2021-08-03 (submission), 2022-06-10 (study start).

Indexed as

AccuracyCranial arteriesDigital PET/CTGCAVasculitis

Identifiers

PMID42625054

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.