Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Esteban M DominguezInstitute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA. edominguez@kumc.edu.ORCID http://orcid.org/0000-0003-3540-4411
Ayelen Moreno-IrustaInstitute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA.ORCID http://orcid.org/0000-0001-6810-6475
Khursheed IqbalInstitute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA.ORCID http://orcid.org/0000-0002-6742-4591
Keting ChenDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, 50011, USA.
Alex FinlinsonDepartment of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Marc ParrishDepartment of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Hiroaki OkaeDepartment of Trophoblast Research, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, 860-0811, Japan.
Takahiro ArimaDepartment of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine, and Department of Molecular Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan.
Michael J SoaresInstitute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA. msoares@kumc.edu.ORCID http://orcid.org/0000-0001-7158-1592
Funding
Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
TROPHOBLAST DIFFERENTIATIONR01HD020676 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES · 1986 to 2026
$10.1M
Trophoblast-Guided Uterine Transformation in the Establishment of PregnancyR01HD105734 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES · 2022 to 2026
$2.2M
Pathways Affecting Trophoblast DevelopmentR01HD112559 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES, Geetu Tuteja · 2024 to 2026
$1.9M
A new animal model for investigating the invasive trophoblast lineageR21HD104071 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI IQBAL, KHURSHEED · 2021 to 2022
$439k
Early Events in Extravillous Trophoblast Cell DifferentiationK99HD115834 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MORENO, AYELEN · 2024 to 2025
$261k
Donald C. Johnson Research Endowment FundHHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD020676HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD104071HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD105734HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD112559HHS | NIH | NICHD | National Center for Medical Rehabilitation Research (NCMRR) HD115834Kansas IDeA Network of Biomedical Research Excellence (K-INBRE) P20 GM103418Lalor Foundation (The Lalor Foundation)NICHD NIH HHS K99 HD115834NICHD NIH HHS R01 HD020676NICHD NIH HHS R01 HD105734NICHD NIH HHS R01 HD112559NICHD NIH HHS R21 HD104071NIGMS NIH HHS P20 GM103418Sosland Foundation (TSF)
6 · The paper itself
Abstract
The expansion and differentiation of trophoblast stem (TS) cells are critical for defining fundamental properties of the placenta. Specialized trophoblast cells called extravillous trophoblast (EVT) cells in human and invasive trophoblast cells in rat, exit the placenta, enter and transform the uterus. This includes the restructuring of uterine spiral arteries, essential for the transfer of nutrients to the fetus. Mechanisms governing invasive trophoblast cell differentiation remain poorly understood. Here, we investigate peroxisome proliferator-activated receptor gamma (PPARG) as a potential regulator of EVT/invasive trophoblast cell development. In first trimester human placentas, PPARG is expressed in the EVT cell column and increases in amount as human TS cells differentiate into EVT cells. PPARG disruption impairs EVT cell differentiation and alters the expression of genes controlling EVT cell lineage development. Rat invasive trophoblast cells similarly express PPARG. Conditional inactivation of PPARG within rat invasive trophoblast cells establishes PPARG as an essential cell-autonomous regulator of invasive trophoblast cells in vivo. In conclusion, PPARG is a conserved regulator of placentation and is essential for directing trophoblast cell-guided uterine transformation.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
PPARG directs trophoblast cell fate and establishment of the uterine-placental interface. · full record | OpenQuestion