Evidence map›Paper›PMID 42625010›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Frequency, predictors, and prognostic impact of intraparotid lymph node recurrence in oral cavity squamous cell carcinoma: a retrospective case-control study.

Nongthombam Surjalata Devi, Smriti Panda, Aanchal Kakkar, Chirom Amit Singh, Rakesh Kumar, Kapil Sikka, Rajeev Kumar, Sanjay Kumar Meena, Kalpa Jyoti Das, Abhinav Singhal and 4 more

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Contextualizing functional outcomes after infrahyoid flap reconstruction for compartmental tongue defects.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nongthombam Surjalata DeviDepartment of Otorhinolaryngology and Head - Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Smriti PandaDepartment of Otorhinolaryngology and Head - Neck Surgery, National Cancer Institute, All India Institute of Medical Sciences, Old Teaching Block, 4th Floor, Jhajjar, New Delhi, Haryana, 110029, India. smriti.panda.87@gmail.com.ORCID http://orcid.org/0000-0003-1257-8611
Aanchal KakkarDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Chirom Amit SinghDepartment of Otorhinolaryngology and Head - Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Rakesh KumarDepartment of Otorhinolaryngology and Head - Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Kapil SikkaDepartment of Otorhinolaryngology and Head - Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Rajeev KumarDepartment of Otorhinolaryngology and Head - Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Sanjay Kumar MeenaDepartment of Radiology, National Cancer Institute, All India Institute of Medical Sciences, Jhajjar, Haryana, New Delhi, India.
Kalpa Jyoti DasDepartment of Nuclear Medicine, All India Institute of Medical Sciences, National Cancer Institute, Haryana, Jhajjar, New Delhi, India.
Abhinav SinghalDepartment of Nuclear Medicine, All India Institute of Medical Sciences, National Cancer Institute, Haryana, Jhajjar, New Delhi, India.
Akash KumarDepartment of Medical Oncology National Cancer Institute, All India Institute of Medical Sciences, Haryana, Jhajjar, New Delhi, India.
Aman SharmaDepartment of Radiotherapy National Cancer Institute, All India Institute of Medical Sciences, Jhajjar, New Delhi, Haryana, India.
Rachit SoodDepartment of Otorhinolaryngology and Head - Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Akoijam Dayananda SinghDepartment of Otorhinolaryngology and Head - Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraparotid lymph node (PLN) recurrence from oral cavity squamous cell carcinoma (OCSCC) is uncommon and inadequately characterised, with limited literature regarding its frequency, predictors, and prognostic implications.

methodsA retrospective analysis was conducted on consecutive patients with OCSCC who underwent upfront surgery at a tertiary care centre from 2022 to 2024. Patients with clinical or radiological evidence of PLN recurrence were identified. A site-matched cohort of 100 consecutive patients with OCSCC treated surgically during the same time frame, and patients with non-PLN recurrences served as controls.

resultsAmong 939 surgically treated OCSCC patients, 22 (2.34%) developed PLN recurrence. Parotid recurrences occurred early, with a median time to detection of 3 months (range, 2-13 months). Presence of greater than 4 metastatic lymph nodes was the only independent predictor of PLN recurrence (OR 5.78, 95% CI 1.43-23.28; p = 0.0136). Patients with PLN recurrences demonstrated significantly inferior survival outcomes. Compared with patients with recurrence outside PLN, patients with PLN recurrences had a higher incidence of tumour location in the gingivobuccal complex, skin involvement, lymphovascular invasion, close margins and belonging to stage IVb. Recurrence in the PLN portends poor OS compared to recurrence outside PLN (HR: 1.98, 95% CI:0.99 to 3.94), with successful salvage possible in only 1 out of 22 patients in the former compared to 9 out of 46 in the latter.

conclusionGreater than 4 metastatic cervical lymph nodes, location in the gingivobuccal complex, skin involvement, stage IVb, lymphovascular invasion, and margins less than 5 mm are predictors of failure in the PLN.

Indexed as

Cervical nodal metastasesIntraparotid nodal recurrenceOral cavity squamous cell carcinomaParotid lymph node recurrenceSurvival outcomes

Identifiers

PMID42625010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.