ReviewNature reviews. Chemistry2026
Subcellular photochemistry for precision spatial protein targeting.
Review in Nature reviews. Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
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Abstract
Proteins with conserved active sites but distinct subcellular localizations, such as mislocalized variants, splicing isoforms and isozymes, are prevalent in disease. However, conventional drug design lacks the spatial control needed for their selective targeting. Subcellular photochemistry offers a solution. Light-activated catalysts with spatiotemporal control convert inert prodrugs into active drugs at the desired subcellular location, without affecting conserved proteins at native sites. In this Perspective, we discuss challenges of targeting mislocalized proteins, principles of subcellular photochemistry for site-specific intervention, strategies for anchoring photocatalysts and key examples of subcellular photocatalytic prodrug activation for precision targeting. We also examine limitations of this approach and propose future solutions. This strategy is expected to expand the druggable target repertoire and advance precision medicine.
Identifiers
42624991What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.