ArticleNature communications2026
Associations of loneliness, social isolation and healthy lifestyle with life expectancy free of major physical disease and mental disorder.
Xuan Wang, Hao Ma, Yoriko Heianza, Zhaoxia Liang, Oscar H Franco, Lu Qi
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Xuan WangDepartment of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai, China.
Hao MaDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Yoriko HeianzaDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Oscar H FrancoJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Funding
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8MNutrigenetics and Nutrigenomics for Precision Weight-Loss Diet InterventionsR01DK115679 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Lu Qi · 2018 to 2026
$5.3MCommon Genetic Variation and Quantitative Diabetes TraitsR01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2008 to 2014
$5.0MGenetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9MObesity Genes, Energy Regulation in Response to Weight-Loss DietsR01DK091718 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2012 to 2021
$4.5MWeight-Loss Diet Intervention on Cardiometabolic Factors of Gut MicrobiotaR01DK100383 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2014 to 2024
$4.2MTOPMed Omics of Type 2 Diabetes and Quantitative TraitsUM1DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNING, ALISA KNODLE · 2021 to 2025
$3.8MRare Sequence Variation and Diabetes Quantitative TraitsU01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2015 to 2019
$3.6MGenome-wide interactions with diet patterns on long-term weight changeR21HL126024 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2015 to 2016
$421kFudan University JIH2645003Y and DGF828028/001NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R21 HL126024NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK091718NIDDK NIH HHS R01 DK100383NIDDK NIH HHS R01 DK115679NIDDK NIH HHS U01 DK078616NIDDK NIH HHS UM1 DK078616U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL071981, HL034594, HL126024U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK115679, DK091718, DK100383, DK078616
6 · The paper itselfAbstract
Loneliness and social isolation are linked to higher risks of mortality and a range of adverse physical diseases and mental disorders, yet the extent to which they affect overall health and quality of life remains unclear. Here we show that loneliness and social isolation are more strongly associated with life expectancy free of mental disorder than with life expectancy free of physical disease. This study includes 277,489 adults from the UK Biobank who are initially free of seven major chronic diseases (type 2 diabetes, cardiovascular disease, chronic respiratory disease, neurodegenerative disease, cancer, depression, and anxiety). At age 50, women and men experiencing both loneliness and social isolation, as compared to their counterparts experiencing neither, live 2.4 and 1.7 fewer years free of physical disease and 3.7 and 5.8 fewer years free of mental disorder, respectively. Notably, the loss of disease-free life expectancy associated with social isolation narrows with healthier lifestyles, but the corresponding association for loneliness was not statistically significant.
Indexed as
Healthy LifestyleLife ExpectancyLonelinessMental DisordersSocial IsolationAdultAgedChronic DiseaseFemaleHumansMaleMiddle AgedQuality of LifeUnited Kingdom
Identifiers
PMID42624836
PMCPMC13493949
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