Evidence map›Paper›PMID 42624776›Full record

ReviewChinese medical journal2026

Aging-, obesity-, and diabetes-related sarcopenia: Pathogenesis and interventions.

Shuang Han, Qianqian Xiong, Qingqian Wu, Chengyan Han, Yingjuan Zhang, Jiahuan Zou, Ruyi Guo, Yue Gao, Zhuo-Xian Meng

Abstract readReview
In one paragraph

Review in Chinese medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuang HanDepartment of Geriatrics, the Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, China.
Qianqian XiongDepartment of Geriatrics, the Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, China.
Qingqian WuZhejiang Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Senile Chronic Diseases, Department of Geriatrics, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, China.
Chengyan HanFaculty of Fisheries, Graduate School of Integrated Science and Technology, Nagasaki University, Bunkyo 1-14, Nagasaki 852-8521, Japan.
Yingjuan ZhangZhejiang Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Senile Chronic Diseases, Department of Geriatrics, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, China.
Jiahuan ZouZhejiang Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Senile Chronic Diseases, Department of Geriatrics, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, China.
Ruyi GuoZhejiang Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Senile Chronic Diseases, Department of Geriatrics, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, China.
Yue GaoZhejiang Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Senile Chronic Diseases, Department of Geriatrics, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, China.
Zhuo-Xian MengDepartment of Pathology and Pathophysiology and Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractAs global aging accelerates, sarcopenia has become an increasingly important public health concern. Although typically recognized as an age-related condition, sarcopenia can develop and progress more rapidly under certain pathological conditions, such as obesity and type 2 diabetes. With the ongoing advancement of related research, the mechanisms underlying sarcopenia are being progressively elucidated. Management strategies include both nonpharmacological and pharmacological interventions. Resistance exercise is currently regarded as one of the most effective and foundational nonpharmacological approaches. Strength-based training programs have been shown to improve muscle mass and strength, reduce functional decline, and lower the risk of falls. However, despite the growing recognition of sarcopenia as a major health issue, particularly among aging populations, no drug has yet been approved by the US Food and Drug Administration as a specific treatment for this condition, due to its complex pathophysiology. This review aims to systematically summarize the epidemiological characteristics and pathogenesis of aging-, obesity-, and diabetes-related sarcopenia and to discuss evidence-based intervention strategies. Future research should focus on elucidating the underlying biological mechanisms, identifying biomarkers for early diagnosis, and developing individualized precision treatment systems.

Indexed as

AgingDiabetes Mellitus, Type 2ObesitySarcopeniaHumansAgingDiabetesInterventionMechanismObesitySarcopenia

Identifiers

PMID42624776
PMCPMC13682805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.