Evidence map›Paper›PMID 42624643›Full record

ArticleBMJ open respiratory research2026

A protocol for the rehabilitation of patients undergoing mechanical ventilation from the ICU to the post-hospital phase: the MOVE-ICUtoHOME, a multicentre randomised controlled trial.

Ada Clarice Gastaldi, Thaís Marina Pires de Campos Biazon, Aníbal Basíle-Filho, Daniele Oliveira Dos Santos, Joana Tambascio, Jéssica Perossi, Janne Marques Silveira, Marcos Gontijo da Silva, Esther Cecilia Wilches-Lunae, Omar Usmani and 1 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06405529 (Rehabilitation of Patients Submitted to Mechanical Ventilation, From the ICU to the Post-hospital Phase), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06405529 nanot yet recruitingnot on this map

Rehabilitation of Patients Submitted to Mechanical Ventilation, From the ICU to the Post-hospital Phase: Blinded Randomized Controlled Clinical Trial, With Economic and Multicenter Evaluation

TypeinterventionalSponsorUniversity of Sao PauloRan2024 to 2027Enrolled206ConditionsEarly Mobilization, Physiotherapy, RehabilitationArmsEarly and intensive mobilization protocol at the ICU and Rehabilitation post-hospital discharge
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ada Clarice GastaldiLaboratory of Assessment Respiratory, Department of Health Sciences, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil ada@fmrp.usp.br.
Thaís Marina Pires de Campos BiazonLaboratory of Assessment Respiratory, Department of Health Sciences, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil.
Aníbal Basíle-FilhoIntensive Care Division, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Daniele Oliveira Dos SantosLaboratory of Assessment Respiratory, Department of Health Sciences, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil.
Joana TambascioLaboratory of Assessment Respiratory, Department of Health Sciences, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil.
Jéssica PerossiLaboratory of Assessment Respiratory, Department of Health Sciences, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil.
Janne Marques SilveiraGraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Marcos Gontijo da SilvaPostgraduate Program in Biotechnology, University of Gurupi, Gurupi, Tocantins, Brazil.
Esther Cecilia Wilches-LunaeFaculty of Health, Universidad del Valle, Cali, Valle del Cauca, Colombia.
Omar UsmaniNational Heart and Lung Institute, Royal Brompton Hospital, Imperial College London, London, UK.
Anamaria Siriani de OliveiraDepartment of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIntensive care unit-acquired weakness (ICU-AW) in patients with acute respiratory failure requiring invasive mechanical ventilation (IMV) is associated with reduced functional exercise capacity and increased mortality. Early mobilisation in the ICU may improve functional outcomes and reduce length of stay; however, evidence remains limited, protocols are heterogeneous and post-discharge rehabilitation is frequently lacking. This study aims to evaluate the effects of a continuous care programme combining early intensive ICU mobilisation with post-hospitalisation rehabilitation on functional exercise capacity, with inflammation, quality of life, mortality and cost-effectiveness as secondary outcomes in critically ill patients receiving IMV. METHODS AND ANALYSIS: This blinded, multicentre, randomised controlled trial will include adult patients undergoing invasive MV for at least 24 hours. Participants will be randomly allocated to one of four groups: intervention group (IG)-Rehab, control group (CG)-Rehab, IG-Home or CG-Home. During hospitalisation, the IG will receive an intensive mobilisation protocol (30-60 minutes/day), while the CG will receive routine care (up to 10 min/day). After hospital discharge, participants will undergo either 8 weeks of face-to-face rehabilitation (Rehab) or a home-based programme (Home), with follow-up for 6 months. Exploratory analyses will evaluate clinical parameters, severity indices, functional status, pulmonary function and mechanics, additional measures of functional exercise capacity, muscle strength and mass, energy expenditure, and symptoms of anxiety and depression. The 2×2 factorial design will allow for the evaluation of the independent effects of in-hospital mobilisation intensity and post-discharge rehabilitation strategy. Statistical analyses will use appropriate parametric or non-parametric tests, with significance set at p<0.05. ETHICS AND DISSEMINATION: The study will follow the Brazilian National Health Council guidelines, the Brazilian General Data Protection Law and Research Electronic Data Capture standards. Results will be disseminated through peer-reviewed journals, scientific meetings and social media. The trial is registered at ClinicalTrials.gov (NCT06405529; 8 May 2024) and follows Consolidated Standards of Reporting Trials guidelines.

Indexed as

Early AmbulationRespiration, ArtificialRespiratory InsufficiencyCost-Benefit AnalysisCritical IllnessExercise ToleranceHumansIntensive Care UnitsLength of StayMulticenter Studies as TopicPatient DischargeQuality of LifeRandomized Controlled Trials as TopicAssisted VentilationCritical CareExercisePatient Outcome AssessmentPulmonary RehabilitationRespiratory Function Test

Identifiers

PMID42624643
PMCPMC13504909

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.