Observational studyRMD open2026
Associations between synovitis and radiographic osteoarthritis progression in the first carpometacarpal and interphalangeal joints: results from the Nor-Hand study.
Observational study in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03083548 (The Nor-Hand Study), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Nor-Hand Study: An Observational Cohort of Hand Osteoarthritis Patients
Who cites it
0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine whether baseline synovitis detected by ultrasound or MRI predicts radiographic osteoarthritis (OA) progression in the first carpometacarpal (CMC1) and interphalangeal joints.
methodsWe included 201 participants with hand OA from the Nor-Hand cohort. The CMC1 and interphalangeal joints were examined by ultrasound (both hands) and MRI (dominant hand) at baseline. Grey-scale synovitis, power Doppler activity and MRI-defined synovitis were scored on 0-3 scales. Bilateral hand radiographs at baseline and follow-up were scored by the same reader. We examined whether synovitis at baseline predicted radiographic progression in the same joint defined as ≥1 increase in Kellgren-Lawrence grade, osteophytes or joint space narrowing or incident erosions. CMC1 and interphalangeal joints were analysed separately using logistic regression with generalised estimating equations, adjusted for age, sex, body mass index and follow-up time.
resultsRadiographic Kellgren-Lawrence progression occurred in 14.7% of CMC1 joints and 10.2% of interphalangeal joints. Baseline grey-scale synovitis was associated with radiographic progression in the CMC1 and interphalangeal joints with the strongest observed association between grade 3 synovitis and Kellgren-Lawrence progression (OR (95% CI) of 9.3 (2.2 to 39.6) and 23.4 (10.4 to 52.9), respectively). Similar relationships were found for power Doppler activity and MRI-defined synovitis.
conclusionsBaseline synovitis detected by ultrasound and MRI was associated with radiographic progression in both CMC1 and interphalangeal joints, supporting inflammation as a relevant prognostic feature across hand OA phenotypes. TRIAL REGISTRATION NUMBER: NCT03083548.
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