Evidence map›Paper›PMID 42624112›Full record

ArticleCell reports2026

Retrosplenial cortex maturation aligns with the transition from infant forgetting to persistent memory.

Benita Jin, Abigail L Yu, Michael W Gongwer, Brian P Kearney, Alfonso Darmawan, Lilit Ohanian, Lucinda Holden-Wingate, Bryan Le, Yuka Nakayama, Sophia A Rueda Mora and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Benita JinDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Cellular and Integrative Physiology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Abigail L YuDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Michael W GongwerDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA; Medical Scientist Training Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Brian P KearneyDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Cellular and Integrative Physiology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Alfonso DarmawanDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lilit OhanianDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lucinda Holden-WingateDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Bryan LeDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yuka NakayamaDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sophia A Rueda MoraDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Anish VelaparthiDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Laura A DeNardoDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: ldenardo@ucla.edu.

Funding

Training Grant in Neurobehavioral GeneticsT32MH073526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GESCHWIND, DANIEL H · 2006 to 2020
$2.4M
Prefrontal circuits underlying the maturation of learned avoidanceR01MH127214 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Laura Anne DeNardo · 2022 to 2026
$2.3M
Investigating circuit-specific effects of high-frequency repetitive transcranial magnetic stimulationF30MH134633 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GONGWER, MICHAEL W. · 2023 to 2024
$81k
NIMH NIH HHS F30 MH134633NIMH NIH HHS R01 MH127214NIMH NIH HHS T32 MH073526
6 · The paper itself

Abstract

Memories formed early in life are rapidly forgotten, whereas those formed later persist. Recent work revealed that physical traces of infant memories endure in the brain but are inaccessible to natural recall. However, the developmental processes regulating this transition remain unclear. Here, we performed a brain-wide developmental screen, revealing age-dependent shifts in regional activation patterns that parallel the emergence of stable memory expression. We focused on the retrosplenial cortex (RSP)-a critical region for adult memory consolidation with poorly understood developmental roles-as a candidate whose refinement may influence memory recall. Persistent memory aligned with increased reactivation of RSP ensembles and dendritic spine refinement. Reactivation of RSP infant learning ensembles a month, but not a week, after learning reinstated forgotten memories, coinciding with dendritic spine refinement on those cells. These findings reveal the developmental trajectory of the RSP, uncovering key maturation features aligning with the transition from forgetting to remembering.

Indexed as

Cerebral CortexMemoryAnimalsDendritic SpinesMaleMental RecallMicebrain clearingCP: neurosciencefear conditioninginfantile amnesialight sheet fluorescence microscopymemoryneural circuitsretrosplenial cortexTRAP2

Identifiers

PMID42624112
PMCPMC13661129

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.