Evidence map›Paper›PMID 42624102›Full record

ReviewStem cell reports2026

Brain organoids in Alzheimer disease and related tauopathies: Challenges and opportunities for translational readiness.

Anuj Guruacharya, Thomas Hartung, Roberta Souza Dos Reis, Natália Chermont Dos Santos Moreira, Liliana Attisano, Silvia Bolognin, Khalid Iqbal, Binita Rajbanshi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anuj GuruacharyaNanil Therapeutics Inc., Toronto, ON, Canada. Electronic address: anuj@naniltx.com.
Thomas HartungDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Biology, University of Konstanz, Konstanz-Egg, Germany.
Roberta Souza Dos ReisDepartment of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.
Natália Chermont Dos Santos MoreiraIntegrated Space Stem Cell Orbital Research Center, Sanford Stem Cell Institute, University of California, San Diego, La Jolla, CA, USA.
Liliana AttisanoDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada.
Silvia BologninInstitute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, the Netherlands.
Khalid IqbalDepartment of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
Binita RajbanshiNanil Therapeutics Inc., Toronto, ON, Canada. Electronic address: bini@naniltx.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A major hurdle in Alzheimer disease research is the failure of mouse models to capture complexities of the human brain that contributes to repeated clinical trial failure. Although the recent US Food and Drug Administration (FDA) Modernization Act 2.0 has enabled non-animal preclinical pathways, brain organoid models of tauopathies remain nascent compared with other disease areas. Here, we identify three challenges for their translational readiness, maturity, disease-relevant cellular complexity, and pathological accuracy, and examine current achievements and emerging solutions. We propose a ten-metric benchmarking framework and discuss the opportunities and remaining challenges for translational readiness in tauopathy modeling.

Indexed as

Alzheimer DiseaseBrainOrganoidsTauopathiesTranslational Research, BiomedicalAnimalsDisease Models, AnimalHumanstau Proteinstau Proteinsbenchmarkingbrain organoidsdrug screeningstandardizationtau aggregationtauopathy

Identifiers

PMID42624102
PMCPMC13555483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.