Evidence map›Paper›PMID 42624087›Full record

ArticleCell chemical biology2026

The degrader gets degraded as cysteine fluctuates.

Junyi Chen, Haopeng Xiao

Abstract read
In one paragraph

Article in Cell chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Junyi ChenDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Haopeng XiaoDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: hpxiao@stanford.edu.

Funding

Defining the landscape and mechanisms of redox regulation of metabolism during agingR00AG073461 · NIA · STANFORD UNIVERSITY · PI Haopeng Xiao · 2025 to 2026
$497k
NIA NIH HHS R00 AG073461
6 · The paper itself

Abstract

In a recent issue of Molecular Cell, Ramage et al. identify a Cullin-RING E3 ubiquitin ligase complex defined by the substrate adaptor LRRC58 that inversely regulates the abundance of LRRC58 and its cognate substrate, CDO1, in response to cysteine levels.

Indexed as

CysteineUbiquitin-Protein LigasesHumansProteolysisCysteineUbiquitin-Protein Ligases

Identifiers

PMID42624087
PMCPMC13609812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.