Evidence map›Paper›PMID 42624000›Full record

ArticleThe journal of physiological sciences : JPS2026

α-mannosidase I-dependent N-linked glycosylation affects hERG channel functional availability during reactivation.

Mengyan Wei, Hui Sun, Yajuan Yin, Yangong Liu, Pu Wang, Kenshi Yoshimura, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono, Ligang Ding and 1 more

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In one paragraph

Article in The journal of physiological sciences : JPS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengyan WeiDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Heart and Metabolism, Shijiazhuang, Hebei, China.
Hui SunDepartment of Orthopedics, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Yajuan YinHebei Key Laboratory of Heart and Metabolism, Shijiazhuang, Hebei, China.
Yangong LiuDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Pu WangDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Kenshi YoshimuraDepartment of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan.
Shinichiro KumeDepartment of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan.
Tatsuki KurokawaDepartment of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan.
Katsushige OnoDepartment of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan. Electronic address: ono@oita-u.ac.jp.
Ligang DingCardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. Electronic address: dingligang@fuwai.com.
Mingqi ZhengDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Heart and Metabolism, Shijiazhuang, Hebei, China. Electronic address: mzheng@hebmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asparagine-linked (N-linked) glycosylation has emerged as an essential post-translational modification to control the number of channels embedded in the plasma membrane as well as to regulate their functional gating properties. The aim of this study was to evaluate the exact role of α-mannosidase I-dependent N-linked glycosylation process in Golgi apparatus on the human rapidly activating delayed rectifier potassium channel, hERG channel. In the heterologous expression system in HEK293 cells, kifunensine, a selective inhibitor of class I α-mannosidase, does not significantly reduce hERG channel current (I

Indexed as

HERGI(hERG)KifunensineKv11.1N-linked glycosylationα-mannosidase I

Identifiers

PMID42624000
PMCPMC13524579

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.