ArticlePoultry science2026
Plasma metabolomic profiling reveals metabolic shifts linked to growth depression in broilers fed high level of valine.
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A study was conducted to investigate the changes of plasma metabolome profiles by which excessive dietary valine modulates the body weight in broilers. A total of 960 male day-old Ross 708 broilers were randomly assigned to two dietary treatments (100% vs. 150% of valine supplementation diet) with 24 replicates per treatment. Corn-soybean meal-based diets were provided until d 42, and plasma samples were collected on d 14 and 42 for untargeted metabolomic profiling. On d 14, 150% valine significantly increased plasma valine concentrations compared with the 100% valine group (False Discovery Rate; FDR < 0.05), with no observed changes in other metabolites or body weight. On d 42, the 150% valine group showed significantly increased plasma valine concentrations (FDR < 0.001) and reduced body weight (P = 0.018) compared with the 100% valine group. Plasma concentrations of leucine and isoleucine were significantly decreased in the 150% group (FDR < 0.05). A significant positive correlation was observed between plasma leucine concentration and body weight (r = 0.29, P = 0.045). Furthermore, plasma concentrations of methylmalonic acid (MMA), 2-hydroxyisovaleric acid (2-HIVA), and alpha-ketoglutarate were significantly increased in the 150% valine group compared to the 100% valine group (FDR < 0.05). MMA (r = -0.34, P = 0.019) and 2-HIVA (r = -0.30, P = 0.040) showed significant negative correlations with body weight. Plasma concentrations of gamma-tocopherol and aspartate were significantly reduced in the 150% valine group on d 42 (FDR < 0.05). Plasma gamma-tocopherol showed a significant positive correlation with body weight (r = 0.34, P = 0.018) and a significant negative correlation with plasma valine (r = -0.43, P = 0.010). In conclusion, the current study indicates that 150% valine acts as a potent metabolic stressor in broiler chickens. This growth depression is driven by branched-chain amino acid antagonism, followed by catabolic byproduct accumulation and subsequent exhaustion of the antioxidant defense system.
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