Evidence map›Paper›PMID 42623647›Full record

ArticleThe American naturalist2026

Eco-Evolutionary Dynamics of Infection and Immunity in Experimentally Founded Lake Populations of Threespine Stickleback.

Daniel I Bolnick, Lucas Eckert, Rowan D H Barrett, Emma Choi, Grant Haines, Andrew P Hendry, Emily V Kerns, Åsa J Lind, Kathryn Milligan-McClellan, Catherine L Peichel and 5 more

Abstract read
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In one paragraph

Article in The American naturalist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Daniel I BolnickDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs, Connecticut 06269.
Lucas EckertDepartment of Biology, McGill University, Montreal, Quebec, Canada.
Rowan D H BarrettDepartment of Biology, McGill University, Montreal, Quebec, Canada.
Emma ChoiDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs, Connecticut 06269.
Grant HainesDepartment of Biology, McGill University, Montreal, Quebec, Canada.
Andrew P HendryDepartment of Biology, McGill University, Montreal, Quebec, Canada.
Emily V KernsDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Åsa J LindDepartment of Biology, McGill University, Montreal, Quebec, Canada.
Kathryn Milligan-McClellanDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269.
Catherine L PeichelDivision of Evolutionary Ecology, Institute of Ecology and Evolution, University of Bern, Bern, Switzerland.
Kristofer T SasserDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Alice R ThorntonDepartment of Biology, University of Massachusetts, Lowell, Massachusetts 01854.
Cole WolfDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Natalie C SteinelDepartment of Biology, University of Massachusetts, Lowell, Massachusetts 01854.
Jesse N WeberDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, Wisconsin 53706.

Funding

Reciprocal genetics of recently-evolved vertebrate immunity and peritoneal helminth counter-adaptationR01AI123659 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI Daniel Imara Bolnick · 2017 to 2026
$3.8M
Mining natural infection variation to find the genetic basis of coevolution between vertebrate hosts and helminth parasitesR35GM142891 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WEBER, JESSE NATHANIEL · 2021 to 2025
$1.9M
Determining the Role of the Host Genetic Background on Immune Response and Gut MicrobiotaR15GM122038 · NIGMS · UNIVERSITY OF ALASKA ANCHORAGE · PI MILLIGAN-MCCLELLAN, KATHRYN C.A. · 2017 to 2017
$427k
NIAID NIH HHS R01 AI123659NIGMS NIH HHS R15 GM122038NIGMS NIH HHS R35 GM142891
6 · The paper itself

Abstract

AbstractHost-parasite interactions are likely to involve eco-evolutionary feedbacks. Parasites can impose strong selection on host immune traits. Evolution of these traits can suppress parasite abundance, which alters the strength of selection. Such eco-evo feedbacks can be hard to document in natural settings, where long-term interactions may have converged on relatively stable equilibria. However, when a species disperses into an unoccupied habitat, it can experience altered parasite abundance (e.g., enemy release) or encounter new parasite genotypes. These perturbations may be followed by observable eco-evolutionary dynamics as the newly assembled host-parasite communities interact and evolve. To test this hypothesis, we experimentally founded nine whole-lake populations of threespine stickleback and tracked changes in the prevalence of a parasite (

Indexed as

Biological EvolutionCestodaCestode InfectionsFish DiseasesHost-Parasite InteractionsSmegmamorphaAnimalsLakeseco-immunologyecological releaseexperimental evolutionGasterosteus aculeatusSchistocephalus solidus

Identifiers

PMID42623647
PMCPMC13495988

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.