ArticleHepatology communications2026
Symptom burden is associated with health-related quality of life in symptomatic adults with primary sclerosing cholangitis.
Article in Hepatology communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Psychometric evaluation of PROMISQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Fatigue and Cognitive Impairment in Adults With Primary Sclerosing Cholangitis: Results From Concept Elicitation Interviews.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
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11 authors.
Funding
Abstract
backgroundThe Primary Sclerosing Cholangitis Symptom Assessment Project (PSC-SAP) is a research initiative aimed at developing regulatory-grade PSC-specific symptom measures. During the initial screening phase for PSC-SAP, patient-reported symptom data were collected from a cohort of symptomatic adults. The current study aims to comprehensively characterize a range of symptoms and identify predictors of symptom burden and mental and physical health-related quality of life (HRQOL).
methodsAdults were primarily recruited through the PSC Partners Patient Registry for this cross-sectional study. Eligible participants completed a telephone-based survey that screened for 13 PSC-associated symptoms experienced in the last month and collected sociodemographic, clinical, and HRQOL scores using the PROMIS (Patient-Reported Outcomes Measurement Information System) global health measure. Multivariable linear regressions were used to model outcomes of total symptom burden and HRQOL.
resultsAmong 126 symptomatic participants, 88% were White, 60% were female, and the mean age was 47 years. The most prevalent symptoms were fatigue (83%) and daytime drowsiness (73%), followed by >60% reporting anxiety, liver pain, brain fog, sleep disturbance, and pruritus. Female sex and cirrhosis were associated with higher symptom burden scores. Factors such as age, history of cholangitis attacks, and inflammatory bowel disease (IBD) were not. Adding a total symptom burden score to initial models substantially increased the explanation of variation in mental HRQOL (from 9% to 48%) and physical HRQOL (from 12% to 51%) scores.
conclusionsAmong symptomatic adults living with PSC, 6 PSC symptoms emerged as highly prevalent. With total symptom burden strongly associated with mental and physical HRQOL, multisymptom assessments should be utilized in future HRQOL studies of PSC and may help improve clinical care for those suffering from PSC.
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