In one paragraphArticle in JMIR research protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
37 authors.
Stephanie DramburgDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany, 49 30450 559839.ORCID 0000-0002-9303-3260 Camilo José Hernandez ToroDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany, 49 30450 559839.ORCID 0000-0003-1242-9018 Josephine TelschowDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany, 49 30450 559839.ORCID 0000-0002-5465-4240 Susanne AbrahamDepartment of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0001-7457-6481 Meslina AlmaciDivision of Allergy and Immunology, Department of Dermatology, Venerology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0009-0008-5664-1970 Anna BehringerDepartment of Dermatology and Allergology Biederstein, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.ORCID 0009-0002-7024-9744 Simone ChristelDepartment of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0009-0008-5757-4837 Angela CorneliusDepartment of Dermatology and Allergy, Medizinische Hochschule Hannover, Hannover, Germany.ORCID 0000-0002-4195-8384 Janina FeustelDepartment of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0009-0001-1907-4064 Sascha FischerDepartment of Dermatology and Allergy, Medizinische Hochschule Hannover, Hannover, Germany.ORCID 0009-0007-7191-8790 Isabelle GloeyerDepartment of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0009-0005-3865-4792 Nadia GüntherDepartment of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0001-9691-6432 Katharina HagemeisterDepartment of Pediatrics, Children's Center Bethel, University Hospital OWL, Bielefeld University, Bielefeld, Germany.ORCID 0009-0009-7156-5707 Eckard HamelmannDepartment of Pediatrics, Children's Center Bethel, University Hospital OWL, Bielefeld University, Bielefeld, Germany.ORCID 0000-0002-2996-8248 Leonard HarriesDepartment of Dermatology and Allergy, Medizinische Hochschule Hannover, Hannover, Germany.ORCID 0009-0005-0425-3077 Annice HeratizadehDepartment of Dermatology and Allergy, Medizinische Hochschule Hannover, Hannover, Germany.ORCID 0000-0002-9231-9865 Nora KnappeDepartment of Pediatrics, Medical Faculty Carl Gustav Carus, University Allergy Center, Technische Universität Dresden, Dresden, Germany.ORCID 0009-0002-9540-8721 Sonja LämmelDeutscher Allergie- und Asthmabund e.V. (German Allergy and Asthma Association e.V.), Mönchengladbach, Germany.ORCID 0009-0002-8849-5994 Eva MoennigDepartment of Dermatology and Allergy, Medizinische Hochschule Hannover, Hannover, Germany.ORCID 0009-0005-3676-4269 Christina PhamDepartment of Dermatology and Allergy, Medizinische Hochschule Hannover, Hannover, Germany.ORCID 0009-0000-3144-5959 Laura RechtienDepartment of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-7997-2712 Thomas ReinholdInstitute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-5169-7029 Christina SchnoppDepartment of Dermatology and Allergology Biederstein, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.ORCID 0009-0005-9603-7848 Christina SchorlemerDepartment of Pediatrics, Children's Center Bethel, University Hospital OWL, Bielefeld University, Bielefeld, Germany.ORCID 0009-0009-8947-2103 Lukas SollfrankDepartment of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-8543-0821 Sophie SpiesDepartment of Dermatology and Allergology Biederstein, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.ORCID 0009-0006-2013-3398 Kristina StamosDepartment of Pediatrics, Medical Faculty Carl Gustav Carus, University Allergy Center, Technische Universität Dresden, Dresden, Germany.ORCID 0009-0007-4122-5926 Michael SticherlingDepartment of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0001-9396-3938 Piera TiernoDepartment of Dermatology and Allergology Biederstein, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.ORCID 0009-0001-4830-4420 Marion TrentmannDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany, 49 30450 559839.ORCID 0009-0005-1831-9065 Christian VogelbergDepartment of Pediatrics, Medical Faculty Carl Gustav Carus, University Allergy Center, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-4881-8368 Hanna WinklerInstitute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-9116-9204 Margitta WormDivision of Allergy and Immunology, Department of Dermatology, Venerology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-3449-1245 Mehrak YoosefiDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany, 49 30450 559839.ORCID 0009-0003-6211-023X Ulrike GrittnerInstitute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-2595-0224 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Background: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, associated with itching, sleep disturbance, and impaired quality of life. Structured patient education can improve disease outcomes, but in-person programs are often unavailable in rural or underserved areas. Digital interventions may help overcome these barriers; however, their efficacy compared with routine care has not been evaluated. Objective: This study aims to assess whether a digitally delivered, interdisciplinary care concept (ADCompanion) is noninferior to routine, real-world care, as available in well-served areas, in reducing disease severity among patients with AD. Secondary objectives include effects on quality of life, pruritus, psychosocial burden, family well-being, and health care costs. Methods: This is a prospective, multicenter, 2-arm, 1:1 randomized noninferiority trial. Participants are stratified by age and disease severity. The intervention group receives standard therapy plus access to a digital platform with training modules and optional video consultations on skin care, nutrition, and psychosocial support. The control group receives routine care, optionally including face-to-face group training where available, and a basic app version for symptom tracking. The primary endpoint is physician-assessed disease severity (Scoring Atopic Dermatitis Index [SCORAD]) at 6 months; secondary endpoints include patient-reported outcomes, itch, quality of life, and disease-related costs. Results: Recruitment of 603 participants across 7 centers in Germany was completed. Data collection was finalized in June 2025. At the time of protocol submission (February 2026), data cleaning had been completed, and the statistical analysis plan was finalized; final results are expected to be published in 2026. Conclusions: This protocol describes a randomized trial designed to evaluate whether digitally delivered interdisciplinary care is noninferior to routine care for patients with AD. The findings of this study will inform the role of digital patient education as a complementary component within established care structures.
Indexed as
Dermatitis, AtopicAdultDigital HealthFemaleHumansMaleMulticenter Studies as TopicPatient Care TeamProspective StudiesQuality of LifeRandomized Controlled Trials as TopicSeverity of Illness IndexTelemedicineatopic dermatitischronic disease managementcounselingdigital health interventioneHealthinterprofessional carenurse-led carenutritional counselingpatient educationpsychosocial supporttelemedicinevideo consultation
Identifiers
PMID42623175
PMCPMC13492303
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