Evidence map›Paper›PMID 42622988›Full record

ArticleSynapse (New York, N.Y.)2026

Intra-Accumbal Infusions of an α

Kazuki Arai, Hiroki Kawashima, Yuri Aono, Yasuhiro Kosuge, John L Waddington, Tadashi Saigusa

Abstract read
In one paragraph

Article in Synapse (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kazuki AraiPharmacology and Dental Pharmacology, Nihon University Graduate School of Dentistry at Matsudo, Matsudo, Chiba, Japan.
Hiroki KawashimaDepartment of Pharmacology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan.
Yuri AonoDepartment of Pharmacology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan.
Yasuhiro KosugeLaboratory of Pharmacology, Nihon University School of Pharmacy, Funabashi, Chiba, Japan.
John L WaddingtonSchool of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Tadashi SaigusaPharmacology and Dental Pharmacology, Nihon University Graduate School of Dentistry at Matsudo, Matsudo, Chiba, Japan.

Funding

Japan Society for the Promotion of ScienceThe Smoking Research Foundation, Japan
6 · The paper itself

Abstract

Though the nucleus accumbens (NAc) is a key terminal region of the mesolimbic dopaminergic system, it is also innervated by noradrenergic inputs from the ventral medulla and contains intrinsic cholinergic neurons. However, the roles of α-adrenoceptors in regulating basal accumbal cholinergic activity remain unclear. This study employed in vivo microdialysis in unanesthetized rats to investigate the role of α

Indexed as

AcetylcholineAdrenergic alpha-2 Receptor AgonistsAdrenergic alpha-2 Receptor AntagonistsDopamineNucleus AccumbensAnimalsBrimonidine TartrateDioxanesDose-Response Relationship, DrugIdazoxanMaleMicrodialysisRatsRats, Sprague-DawleyReceptors, Adrenergic, alpha-2(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane2-methoxyidazoxanAcetylcholineAdrenergic alpha-2 Receptor AgonistsAdrenergic alpha-2 Receptor AntagonistsBrimonidine TartrateDioxanesDopamineIdazoxanReceptors, Adrenergic, alpha-2acetylcholinedopaminein vivo microdialysisnucleus accumbensratα2‐adrenoceptors

Identifiers

PMID42622988
PMCPMC13492509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.