Evidence map›Paper›PMID 42622926›Full record

ArticleMolecular biomedicine2026

Deletion of Pleiotrophin protects against high-fat diet-induced liver metabolic disease, independently of the sexual dimorphism in dietary response.

Héctor Cañeque-Rufo, Agata Zuccaro, Marta Inmaculada Sanz-Cuadrado, Federica Ruin, Ángela Olivera-Rodríguez, Javier Pizarro-Delgado, María Limones, Jimena Pita-Santibáñez, María Gracia Sánchez-Alonso, Julio Sevillano and 5 more

Abstract read
In one paragraph

Article in Molecular biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Héctor Cañeque-RufoDepartment of Chemistry and Biochemistry, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Agata ZuccaroDepartment of Chemistry and Biochemistry, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Marta Inmaculada Sanz-CuadradoDepartment of Chemistry and Biochemistry, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Federica RuinDepartment of Systems Medicine, University Hospital of Padua, Padua, Italy.
Ángela Olivera-RodríguezDepartment of Chemistry and Biochemistry, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Javier Pizarro-DelgadoDepartment of Chemistry and Biochemistry, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
María LimonesDepartment of Chemistry and Biochemistry, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Jimena Pita-SantibáñezDepartment of Chemistry and Biochemistry, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
María Gracia Sánchez-AlonsoDepartment of Chemistry and Biochemistry, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Julio SevillanoDepartment of Chemistry and Biochemistry, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Irma García-MartínezInstituto de Investigaciones Biomédicas Sols-Morreale (CSIC-UAM), Madrid, 28029, Spain.
Ángela M ValverdeInstituto de Investigaciones Biomédicas Sols-Morreale (CSIC-UAM), Madrid, 28029, Spain.
Esther GramageDepartment of Health and Pharmaceutical Sciences, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Gonzalo HerradónDepartment of Health and Pharmaceutical Sciences, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
María Del Pilar Ramos-ÁlvarezDepartment of Chemistry and Biochemistry, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain. pramos@ceu.es.ORCID http://orcid.org/0000-0002-7727-7783

Funding

Comunidad de Madrid P2022/BMD-7227Spanish National Plan for Scientific and Technical Research and Innovation PID2021-123865OB-I00
6 · The paper itself

Abstract

Obesity is a global health problem linked to the development of metabolic syndrome and comorbidities such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). Pleiotrophin (PTN) is a cytokine known for its role in tissue regeneration and energy metabolism. However, its function in hepatic metabolism and its role in MASLD progression remain to be elucidated. Here, we investigated the contribution of PTN to hepatic metabolism using male and female wild-type (Ptn

Indexed as

Carrier ProteinsCytokinesDiet, High-FatGene DeletionMetabolic DiseasesSex CharacteristicsAnimalsFatty LiverFemaleHepatocytesHumansInsulin ResistanceLiverMaleMiceMice, Inbred C57BLCarrier ProteinsCytokinespleiotrophinHigh-fat dietMASHMASLDMetabolic syndromeObesityPleiotrophin

Identifiers

PMID42622926
PMCPMC13493653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.