Evidence map›Paper›PMID 42622910›Full record

ArticleInternational journal of implant dentistry2026

Accuracy of CBCT and dental-MRI for detecting peri-implant bone defects at single titanium implants: an in-vitro pilot study.

Katharina Hartung, Nikolai Miotk, Arne Lauer, Franz Sebastian Schwindling, Mathias Nittka, Ali Özen, Ute Ludwig, Jan-Bernd Hövener, Michael Bock, Tabea Flügge and 5 more

Abstract read
In one paragraph

Article in International journal of implant dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Katharina HartungDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Nikolai MiotkDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Arne LauerDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Franz Sebastian SchwindlingDepartment of Prosthetic Dentistry, Medical University of Innsbruck, Innsbruck, Austria.
Mathias NittkaResearch & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany.
Ali ÖzenDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Ute LudwigDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jan-Bernd HövenerDepartment of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
Michael BockDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Tabea FlüggeDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Belin, corporate member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Anne-Katrin EisenbeissDepartment of Oral and Maxillofacial Surgery, University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany.
Peter RammelsbergDepartment of Prosthodontics, Heidelberg University Hospital, Heidelberg, Germany.
Sabine HeilandDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Martin BendszusDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Tim HilgenfeldDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. tim.hilgenfeld@med.uni-heidelberg.de.ORCID https://orcid.org/0000-0002-3458-8899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the reliability and accuracy of optimized dental-MRI (dMRI) for detecting and classifying peri-implant bone defects around single titanium implants.

methods48 titanium implants were inserted into bovine ribs. 24 implants had surrounding standardized defects (1-wall, 2-wall, 3-wall, 4-wall) in two sizes (1 mm and 3 mm), while the other 24 implants showed no peri-implant bone defects. CBCT and dMRI were performed and analyzed twice by two readers. 3 Tesla MRI was conducted using an innovative intraoral coil and a novel, T1-weighted sequence for metal artifact reduction (CS-SEMAC). Cohen's Kappa (κ), sensitivity, and specificity were assessed for bone defect detection, size, and type. Modality differences were evaluated using the exact McNemar test and Firth penalized-likelihood logistic regression.

resultsFor bone defect detection, almost perfect intra-/inter-rater reliability (κ-value range: 0.958-1) was found for both imaging modalities, with high sensitivity/specificity (CBCT 100%/100%, 95% CI 0.962-1.000/0.962-1.000; MRI 98%/100%, 95% CI 0.927-0.998/0.962-1.000), confirmed by Firth regression (p = 0.22). For defect type classification, both CBCT (κ-value range: 0.884-0.913) and MRI (κ-value range: 0.794-0.942) demonstrated almost perfect intra-/inter-rater reliability. Overall sensitivity/ specificity were 86%/99% (95% CI 0.780-0.926 and 0.985-0.995) for CBCT and 84%/99% (95% CI 0.755-0.910 and 0.985-0.995) for dMRI, with no significant difference between modalities (Firth-adjusted OR 0.85, 95% CI 0.38-1.88, p = 0.68).

conclusionsUnder optimized ex vivo conditions, dMRI offers a promising reliability and accuracy for identifying and classifying peri-implant bone defects around single titanium implants. High-resolution dMRI facilitates radiation-free, three-dimensional peri-implant tissue visualization.

Indexed as

Cone-Beam Computed TomographyDental ImplantsMagnetic Resonance ImagingAnimalsCattleIn Vitro TechniquesPilot ProjectsReproducibility of ResultsRibsSensitivity and SpecificityTitaniumDental ImplantsTitaniumCBCTDental implantsMRIPeri-implantitis

Identifiers

PMID42622910
PMCPMC13493749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.