ArticleCurrent allergy and asthma reports2026
Central Compartment Atopic Disease Within the Chronic Upper Airway Inflammatory Continuum: A Scoping Review of Sinonasal Compartmentalization and Type-2 Airway Disease.
Article in Current allergy and asthma reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewTo map evidence supporting a chronic upper airway inflammatory continuum (CUAIC) linking localized allergic inflammation, central compartment atopic disease (CCAD), diffuse type 2 chronic rhinosinusitis (CRS), and broader T2-airway disease. RECENT
findingsA scoping review of five databases identified 58 studies from January 2014 to April 2026. Evidence described a non-linear spectrum extending from local allergic rhinitis and localized sinonasal responses to CCAD, diffuse CRSwNP, and lower-airway comorbidity. Endoscopy provided the clearest anatomical anchor, with CCAD representing a recognizable central-compartment phenotype. Radiological findings ranged from limited central changes to multi-sinus opacification, while biomarkers suggested enrichment from local allergic markers to tissue eosinophilia, type 2 cytokine activity, and lower-airway traits. The CUAIC conceptualizes CCAD as an intermediate or overlapping phenotype between localized sinonasal allergy and broader type 2 airway disease. It reflects persistence, overlap, or expansion rather than an obligatory sequence. Prospective longitudinal studies are needed to validate its clinical utility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.