SynthesisInternational ophthalmology2026
Macular perfusion analysis using optical coherence tomography angiography post rhegmatogenous retinal detachment repair: a systematic review and meta-analysis.
Synthesis in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEvaluating rhegmatogenous retinal detachment (RRD) repair traditionally focuses on anatomical reattachment and visual acuity. Understanding macular perfusion changes post-repair offers a more comprehensive assessment. Optical coherence tomography angiography (OCTA) non-invasively visualizes retinal microvasculature, enabling detailed perfusion analysis.
methodsOur protocol was registered (PROSPERO CRD42024533072). We searched PubMed, Scopus, ScienceDirect, and Cochrane databases (from inception to November 2024) for studies comparing OCTA parameters between post-repair RRD eyes and controls. Analyzed parameters included foveal avascular zone (FAZ) area, foveal (FVD) and parafoveal vascular density (PFVD), choriocapillaris (CC) perfusion, and best-corrected visual acuity (BCVA). Data were analyzed for macula-ON and macula-OFF groups using a random-effects model.
resultsTwenty studies comprising 686 RRD eyes (231 macula-ON, 455 macula-OFF) and 686 control eyes were analyzed. In macula-OFF cases, FAZ area remained significantly enlarged post-repair in both superficial capillary plexus (SCP) (0.06 mm
conclusionsDespite successful anatomical repair of RRD, persistent alterations in macular perfusion parameters were observed, particularly in the macula-OFF group. The enlarged FAZ area and reduced PFVD and CC perfusion density suggest lasting changes in the retinal microvasculature post-repair. However, significant improvement in BCVA, especially in macula-OFF cases, indicates that functional recovery may occur despite these vascular changes. These findings highlight the need for comprehensive assessment beyond isolated perfusion metrics when evaluating surgical success in RRD repair.
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