Evidence map›Paper›PMID 42622764›Full record

ArticleClinical rheumatology2026

Digital physical-activity engagement and 12-week patient-reported outcomes in inflammatory arthritis: a retrospective real-world cohort study.

Dmytro Fedkov, Daria Koliadenko, Liubov Petelytska, Christine Peine, Felix Lang, Abdullah Khalil, Oleg Iaremenko

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Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Dmytro FedkovDepartment of Internal Medicine #3, Bogomolets National Medical University, 13 Blvd Shevchenka, Kyiv, 01032, Ukraine. fedkovdmytro@gmail.com.ORCID http://orcid.org/0000-0001-7965-9438
Daria KoliadenkoDepartment of Internal Medicine #3, Bogomolets National Medical University, 13 Blvd Shevchenka, Kyiv, 01032, Ukraine.ORCID http://orcid.org/0000-0002-9562-9367
Liubov PetelytskaDepartment of Internal Medicine #3, Bogomolets National Medical University, 13 Blvd Shevchenka, Kyiv, 01032, Ukraine.ORCID http://orcid.org/0000-0001-8330-8681
Christine PeineMidaia GmbH, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6500-7180
Felix LangMidaia GmbH, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6102-2674
Abdullah KhalilMidaia GmbH, Heidelberg, Germany.ORCID http://orcid.org/0009-0003-9969-5462
Oleg IaremenkoDepartment of Internal Medicine #3, Bogomolets National Medical University, 13 Blvd Shevchenka, Kyiv, 01032, Ukraine.ORCID http://orcid.org/0000-0003-2095-5819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical activity is a key component of inflammatory arthritis (IA) management, yet real-world evidence on digital exercise-support tools remains limited.

objectivesTo examine whether physical-activity action plan (PA_AP) engagement over 12 weeks is associated with changes in the Health Assessment Questionnaire (HAQ), pain, physical component score (PCS), patient global assessment (PGA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and Functional Index (BASFI).

methodsThis retrospective cohort study included adults with IA using a digital application. Associations between PA_AP engagement and 12-week outcomes were estimated using ANCOVA models adjusting for age, sex, diagnosis, and baseline values. Exploratory analyses assessed individual PA_APs.

resultsAmong 2924 users, paired 12-week data were available for HAQ (n = 285), pain (n = 930), PGA (n = 928), PCS (n = 165), BASDAI (n = 163), and BASFI (n = 84). Overall, PA_AP engagement was associated with minor worsening in HAQ (β = 0.36, 95% CI 0.19-0.52), while no statistically significant associations were observed for PCS, PGA, BASDAI, or BASFI. Exploratory analyses identified modest statistically significant benefits for two structured modules: Exercise training, with reductions in pain (β = - 5.99, 95% CI - 9.12 to - 2.87) and PGA (β = - 5.83, 95% CI - 9.04 to - 2.62), and Yoga for rheumatism, which improved PGA (β = - 5.65, 95% CI - 10.21 to - 1.09) and showed a favourable trend for pain.

conclusionIn this real-world IA cohort, structured, disease-activity-tailored exercise and adapted yoga content delivered statistically significant benefits. However, overall PA_AP engagement showed no gains in functional or disease-activity outcomes, suggesting that more personalised, progressive, clinically guided digital physical-activity modules could offer greater therapeutic value. Key Points • Non-personalised physical-activity action plans produced only minor short-term changes in function and disease activity, with no consistent clinically meaningful improvement. • Two structured and partially individualised modules (tailored exercise training and adapted yoga) showed modest but statistically significant symptomatic benefits, particularly for pain and PGA. • Digital exercise tools may be most effective when they provide symptom-responsive adaptation, personalised progression, and physiotherapy-informed calibration rather than generic, non-progressive programmes.

Indexed as

ArthritisArthritis, RheumatoidExerciseExercise TherapyPatient Reported Outcome MeasuresAdultAgedDigital HealthFemaleHumansMaleMiddle AgedPain MeasurementRetrospective StudiesSeverity of Illness IndexTreatment OutcomeExercise therapyMobile applicationsPhysical activityPsoriatic arthritisRheumatoid arthritisSpondyloarthritis

Identifiers

PMID42622764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.