Evidence map›Paper›PMID 42622744›Full record

ArticleMolecular diversity2026

Palladium-catalyzed borylative coupling of hypervalent iodine diazo reagents with boranes for the synthesis of organoboron carboxylate.

Haoxuan Yuan, Siyu Wu, Xinke Zhang, Abdulla Yusuf, Wenhao Hu, Yu Qian

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Haoxuan YuanCollege of Chemistry and Environmental Science, The Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashi University, Kashi, 844000, China.
Siyu WuState Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Xinke ZhangState Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Abdulla YusufCollege of Chemistry and Environmental Science, The Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashi University, Kashi, 844000, China. kashidaxue_abudula@163.com.
Wenhao HuState Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Yu QianCollege of Chemistry and Environmental Science, The Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashi University, Kashi, 844000, China. qianyu5@mail.sysu.edu.cn.

Funding

Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery 2023B1212060022Key-Area Research and Development Program of Guangdong Province 2022B1111050003Key-Area Research and Development Program of Guangdong Province 2022B1111070004Natural Science Foundation of Guangdong Province 2026A1515011535The open project of The Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry KSUZDSYS202401Xinjiang Talent Development Fund XJRC-2025-KJ-PY-KJLJ-121Xinjiang Talent Development Fund XJRC-2025-KJ-YJ-CXPT-190
6 · The paper itself

Abstract

A palladium-catalyzed coupling of hypervalent iodine diazo compounds with 2-arylpyridine borane complexes has been developed, enabling an efficient synthesis of diverse organoboron carboxylates in good to excellent yields with high chemoselectivity. Unlike traditional carbene B-H insertion reactions that form C-B bonds, this method proceeds via a borane-to-carbene hydride transfer pathway, providing a new strategy for organoboron carboxylate construction. The reaction shows broad substrate scope, good functional-group tolerance, and is scalable. Mechanistic studies support formation of a Pd-carbene intermediate followed by hydride transfer and rearrangement. Preliminary biological evaluation shows that selected products exhibit antiproliferative activity against multiple cancer cell lines, with compound 3m showing the highest potency (IC

Indexed as

Anticancer activityHypervalent iodine diazo compoundsMetal carbenesOrganoboron carboxylate complexes

Identifiers

PMID42622744

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.