Evidence map›Paper›PMID 42622682›Full record

ArticleJournal of neurology2026

Episodic memory deficits are associated with social cognitive impairments in multiple sclerosis.

Bruno Brochet, Thibault Moreau, Aurore Saubusse, Julie Charré-Morin, Delphine Lamargue, Mathilde Deloire, Aurélie Ruet

Registry-linked trialAbstract readClinical Study
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02708927 (Emotional Processing, Family Life, Friendship and Social Integration in Patients With Multiple Sclerosis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02708927 nacompletednot on this map

Emotional Processing, Family Life, Friendship and Social Integration in Patients With Multiple Sclerosis

TypeinterventionalSponsorUniversity Hospital, BordeauxRan2016 to 2019Enrolled91ConditionsMultiple SclerosisArmsClinical evaluation, Cognitive evaluation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bruno BrochetUniversité de Bordeaux, INSERM, U1215, Neurocentre Magendie, 146, Rue Léo Saignat, 33077, Bordeaux, France. Bruno.brochet@u-bordeaux.fr.ORCID http://orcid.org/0000-0003-3824-2796
Thibault MoreauService de Neurologie, CHU de Dijon, 21000, Dijon, France.ORCID http://orcid.org/0009-0001-1130-7214
Aurore SaubusseService de Neurologie, CHU de Bordeaux, 33000, Bordeaux, France.
Julie Charré-MorinService de Neurologie, CHU de Bordeaux, 33000, Bordeaux, France.ORCID http://orcid.org/0009-0005-3116-6630
Delphine LamargueUniversité de Bordeaux, INSERM, U1215, Neurocentre Magendie, 146, Rue Léo Saignat, 33077, Bordeaux, France.ORCID http://orcid.org/0000-0001-8415-889X
Mathilde DeloireDRCI, CHU de Bordeaux, 33000, Bordeaux, France.
Aurélie RuetUniversité de Bordeaux, INSERM, U1215, Neurocentre Magendie, 146, Rue Léo Saignat, 33077, Bordeaux, France.ORCID http://orcid.org/0000-0002-0020-8739

Funding

Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques 2015
6 · The paper itself

Abstract

BACKGROUND/

objectivesMultiple sclerosis (MS) is associated with cognitive impairments affecting attention, processing speed, executive functions, and episodic memory. Social cognition (SC), encompassing emotional processing and theory of mind (ToM), is also impaired in MS. However, its relationship with common cognitive functioning is not well defined. The objective of this study was to investigate the relationships between social and non-social cognitive impairments, focusing on episodic memory, executive functions, and information processing speed in people with MS.

methodsWe assessed 58 relapsing-remitting MS patients and 30 healthy controls using neuropsychological and SC tests to explore these associations.

resultsMS patients showed significant deficits in emotional recognition and ToM, which correlated strongly with episodic memory performance but showed weak correlations with executive functions and not with processing speed. Multivariate analyses indicated that episodic memory accounted for a significant portion of the variance in emotional processing and ToM abilities.

conclusionsThese results suggest that episodic memory deficits represent an important cognitive correlate of SC in MS, underscoring the need to consider memory function in understanding and addressing SC difficulties in this population. CLINICAL TRIALS: Clinical Trails gov ID NCT02708927) This study received approval from the ethics committee (Comité de Protection des Personnes [CPP] Sud-Ouest et Outre-Mer III) (ID-RCB: 2015-A01282-47).

Indexed as

Cognition DisordersCognitive DysfunctionMemory DisordersMemory, EpisodicMultiple SclerosisMultiple Sclerosis, Relapsing-RemittingSocial CognitionAdultEmotionsExecutive FunctionFemaleHumansMaleMiddle AgedNeuropsychological TestsProcessing SpeedCognitive impairmentEpisodic memoryMultiple sclerosisSocial cognitionTheory of mind

Identifiers

PMID42622682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.