ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2026
Multicenter ProKnow-based plan evaluation of postprostatectomy salvage radiotherapy patients using SPPORT and RADICALS-HD trial-defined dose constraints.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
purposeSalvage radiotherapy (sRT) after radical prostatectomy is the only curative treatment for patients with biochemical recurrence. Sparing organs at risk (OAR) is essential to minimize long-term toxicity. This multicenter study analyzed radiotherapy plans from Bavarian university centers within the Bavarian Cancer Research Center (BZKF) using dose-volume constraints from the SPPORT and RADICALS-HD trials.
methodsIn this retrospective multicenter analysis, 117 patients treated with prostate bed sRT were included. Radiotherapy plans were anonymized and evaluated using ProKnow (Elekta, Stockholm, Sweden). Scorecards based on SPPORT and RADICALS-HD dose-volume constraints were used to assess plan quality. Planning metrics, including planning target volume (PTV), D95, conformality index, and V66, were recorded, and their correlations with OAR dose were analyzed.
resultsThe median PTV was 213.9 cm
conclusionThis multicenter analysis demonstrates that dose-volume objectives in the postoperative salvage setting can be reliably assessed across centers and are met in the majority of cases. ProKnow enables structured and objective plan evaluation and serves as a useful tool for standardized quality assurance.
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