Evidence map›Paper›PMID 42622654›Full record

ArticleSurgical endoscopy2026

Long-term outcomes and recurrence patterns of endoscopic papillectomy for ampullary tumors: a 15-year experience from a large tertiary center in China.

Zimeng Wang, Nan Ru, Junrong Liang, Song Su, Yawei Bi, Longsong Li, Bo Zhang, Xiangdong Wang, Enqiang LingHu, Ningli Chai

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Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zimeng Wang *Senior Department of Gastroenterology, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Nan Ru *Senior Department of Gastroenterology, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Junrong LiangDepartment of Gastroenterology, 987, Hospital of the Joint Logistics Support Force of the People's Liberation Army, Baoji Shaanxi, 721000, China.
Song SuSenior Department of Gastroenterology, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Yawei BiSenior Department of Gastroenterology, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Longsong LiSenior Department of Gastroenterology, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Bo ZhangSenior Department of Gastroenterology, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Xiangdong WangSenior Department of Gastroenterology, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Enqiang LingHuSenior Department of Gastroenterology, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Ningli ChaiSenior Department of Gastroenterology, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China. chainingli@vip.163.com.

Funding

China Postdoctoral Science Foundation 2023T160785National Natural Science Foundation of China 12126608National Natural Science Foundation of China 82400755
6 · The paper itself

Abstract

BACKGROUND AND

aimsEndoscopic papillectomy (EP) is an established treatment for ampullary tumors. This study aimed to analyze recurrence patterns and risk factors in a large cohort with long-term follow-up.

methodsPatients who underwent EP for ampullary tumors at a large tertiary center from January 2010 to June 2025 were retrospectively reviewed. Cumulative recurrence rates were estimated using Kaplan-Meier analysis, and Gaussian kernel density estimation was employed to explore dynamic recurrence patterns. Cox proportional hazards model was used to identify risk factors for recurrence. Sensitivity analysis was conducted in a subgroup with at least a 5-year follow-up.

resultsA total of 262 patients were enrolled, with an endoscopic treatment success rate of 85.1%. Follow-up analysis included 218 patients, and the 1-year, 3-year, and 8-year cumulative recurrence rates were 4.2, 11.5, and 14.1%, respectively. Recurrences occurred predominantly within 2-year post-procedure, peaking at 14.9 months. Carcinoma was independently associated with an increased risk of recurrence (hazard ratios = 3.878, P = 0.025). Cumulative recurrence risk was significantly higher in carcinoma than in low-grade dysplasia.

conclusionWe recommend intensified follow-up during the peak recurrence period as a reasonable strategy. Histology-based personalized surveillance is warranted in routine practice.

Indexed as

Ampulla of VaterEndoscopic mucosal resectionRecurrenceTreatment outcome

Identifiers

PMID42622654

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.