Evidence map›Paper›PMID 42622653›Full record

ArticleSurgical endoscopy2026

Adjunctive fibrin glue for the prevention of bleeding after endoscopic submucosal dissection of gastroesophageal lesions: a systematic review and meta-analysis.

Leonardo Corrêa Süffert, Bernardo de Faria Moraes, Henrique Steffens de Abreu, Luis Pedro Possapp Beis, Eliabe S Abreu, Pedro Robson Costa Passos, Igor Boechat Silveira, Guilherme Grossi Lopes Cançado, Matheus Cavalcante Franco

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Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leonardo Corrêa SüffertSchool of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, 6681 Ipiranga Av, Partenon, Porto Alegre, RS, 90619-900, Brazil. leo.correasuffert@gmail.com.ORCID http://orcid.org/0009-0009-7210-6713
Bernardo de Faria MoraesSchool of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Henrique Steffens de AbreuSchool of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, 6681 Ipiranga Av, Partenon, Porto Alegre, RS, 90619-900, Brazil.
Luis Pedro Possapp BeisSchool of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, 6681 Ipiranga Av, Partenon, Porto Alegre, RS, 90619-900, Brazil.
Eliabe S AbreuDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Pedro Robson Costa PassosSchool of Medicine, Universidade do Ceará, Fortaleza, Brazil.
Igor Boechat SilveiraSchool of Medicine, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
Guilherme Grossi Lopes CançadoInstituto Alfa de Gastroenterologia, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Matheus Cavalcante FrancoDivision of Gastroenterology and Nutrition, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimBleeding after endoscopic submucosal dissection (ESD) is a relevant complication that may require urgent endoscopic intervention. Emerging evidence suggests that fibrin glue use after conventional hemostasis may reduce bleeding. This meta-analysis aimed to evaluate the association between fibrin glue use and the prevention of post-ESD ulcer bleeding in gastroesophageal lesions.

methodsPubMed, embase, and Cochrane CENTRAL were searched for randomized controlled trials (RCTs) and observational studies evaluating the use of fibrin glue as an adjunctive treatment after ESD for bleeding prevention. Outcomes were analyzed using risk ratios (RR) with 95% confidence intervals (CI), and heterogeneity was assessed using I

resultsSeven studies were included (2 RCTs and 5 observational studies), totaling 2141 patients who underwent ESD. Fibrin glue did not decrease the incidence of post-ESD overall bleeding in gastroesophageal lesions (RR: 0.67; 95% CI 0.29-1.57; p = 0.354; I

conclusionFibrin glue was not associated with a reduction in bleeding after ESD of gastroesophageal lesions. However, future studies should further evaluate its impact on high-risk subpopulations.

Indexed as

Endoscopic submucosal dissectionFibrin tissue adhesiveHemorrhage

Identifiers

PMID42622653

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.