ArticlePediatrics international : official journal of the Japan Pediatric Society
Loci Associated With Susceptibility to Biliary Atresia-A Genome-Wide Association Study in Taiwan.
Article in Pediatrics international : official journal of the Japan Pediatric Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBiliary atresia (BA) is the leading cause of pediatric liver transplantation worldwide. However, the genetic background remains unclear in most patients. In this genome-wide association study (GWAS), we aimed to identify genetic loci that contribute to susceptibility to BA.
methodsWe recruited 189 BA patients (85 males and 104 females) and 558 non-BA controls (275 males and 283 females) for this GWAS analysis using the Axiom Genome-Wide TWB 2.0 Array with 686,463 single-nucleotide polymorphisms (SNPs). The MassARRAY Sequenom analysis was then applied to validate the identified top SNPs.
resultsWe identified rs139120621 (odds ratio [OR] = 17.31, p = 2.78 × 10
conclusionsWe identified novel loci of BA susceptibility SNPs in a Taiwanese cohort by the GWAS analysis. These findings shed light on the genetic factors in the pathophysiology of BA that might be applied to the future development of therapeutic agents for BA patients.
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