Evidence map›Paper›PMID 42622016›Full record

ArticleACS medicinal chemistry letters2026

Synthetic Diastereomers of the Fungal Cycloheptapeptide Paraisariamide A Retain Ternatin-Like Biological Activity.

Sophia E Bonar, Daphne R Mattos, Takumi Arai, Yui Tagami, Dean A Buch, Richard M Tehan, Kerry L McPhail, Shinya Oishi, Jane E Ishmael

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sophia E BonarDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.
Daphne R MattosDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.
Takumi AraiLaboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan.
Yui TagamiLaboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan.
Dean A BuchDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.
Richard M TehanDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.ORCID https://orcid.org/0000-0001-7039-3610
Kerry L McPhailDepartment of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, Utah 84103, United States.ORCID https://orcid.org/0000-0003-2076-1002
Shinya OishiLaboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan.ORCID https://orcid.org/0000-0002-2833-2539
Jane E IshmaelDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.ORCID https://orcid.org/0000-0003-4574-2801

Funding

Modulation of Protein Biogenesis and Secretion by Natural Product Translocon LigandsR01GM132649 · NIGMS · OREGON STATE UNIVERSITY · PI ISHMAEL, JANE E, MCPHAIL, KERRY LEIGH · 2019 to 2024
$2.0M
Research Training in Natural Product Complementary and Integrative Health - Diversity Supplement to T32 Predoctoral Training GrantT32AT010131 · NCCIH · OREGON STATE UNIVERSITY · PI TAIFO MAHMUD, RICHARD B VAN BREEMEN · 2020 to 2026
$1.8M
NCCIH NIH HHS T32 AT010131NIGMS NIH HHS R01 GM132649
6 · The paper itself

Abstract

Paraisariamides (Psds) are a family of fungal N-methylated cyclic heptapeptides with structural similarity to the translation eukaryotic elongation factor 1A inhibitor ternatin. Initial characterization of the eight known Psds A-H revealed a complex biological activity profile; Psd A and Psds E-H showed differential cytotoxicity to HCT116 colon cancer cells, whereas Psds B-D were inactive. Here, we report that Psd A is a weak inhibitor of total protein synthesis and that three synthetic diastereomers of Psd A retain comparable pharmacological activity. Psd A and all structural variants decreased the level of expression of extracellular

Indexed as

didemnin Bfungal pathogenprotein synthesis inhibitorSUnSET assayternatin peptide

Identifiers

PMID42622016
PMCPMC13488079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.