Evidence map›Paper›PMID 42621916›Full record

ArticleACS medicinal chemistry letters2026

Nicotinamide-Based Covalent Inhibitors of tRNA (m

Isao Masuda, Simon D P Baugh, Kevin McClay, Ryan J Ford, Lily Tayag, Eric D Strobel, Thomas Grant, Samantha A DeSando, Hongjuan Guo, Thomas Christian and 7 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Isao MasudaDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.ORCID https://orcid.org/0000-0001-9385-4424
Simon D P BaughFox Chase Therapeutics Discovery Inc. Doylestown, Pennsylvania 18902, United States.
Kevin McClayFox Chase Therapeutics Discovery Inc. Doylestown, Pennsylvania 18902, United States.
Ryan J FordConifer Point Pharmaceuticals, Doylestown, Pennsylvania 18902, United States.
Lily TayagDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.
Eric D StrobelFox Chase Therapeutics Discovery Inc. Doylestown, Pennsylvania 18902, United States.
Thomas GrantDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.
Samantha A DeSandoFox Chase Therapeutics Discovery Inc. Doylestown, Pennsylvania 18902, United States.
Hongjuan GuoDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.
Thomas ChristianDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.
Diana Bao HangDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.
Zheng RuanDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.
John L KulpConifer Point Pharmaceuticals, Doylestown, Pennsylvania 18902, United States.
Katie B FreemanFox Chase Therapeutics Discovery Inc. Doylestown, Pennsylvania 18902, United States.ORCID https://orcid.org/0000-0003-4021-8808
Ya-Ming HouDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.ORCID https://orcid.org/0000-0001-6546-2597
Allen B ReitzFox Chase Therapeutics Discovery Inc. Doylestown, Pennsylvania 18902, United States.ORCID https://orcid.org/0000-0003-2780-4044
Dipti KanabarFox Chase Therapeutics Discovery Inc. Doylestown, Pennsylvania 18902, United States.ORCID https://orcid.org/0000-0001-6541-6494

Funding

tRNA in codon usageR35GM134931 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING · 2020 to 2025
$5.4M
Discovery of Gram-negative permeable chemical probes for tRNA methylationR01AI139202 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING · 2019 to 2022
$2.4M
NIAID NIH HHS R01 AI139202NIGMS NIH HHS R35 GM134931
6 · The paper itself

Abstract

Bacterial tRNA (m

Indexed as

AdoMet (S-adenosyl methionine)Antibacterial drug discoverycovalent inhibitionGram-negative bacteriastructure-based drug designTrmD (tRNA (m1G37) methyltransferase)

Identifiers

PMID42621916
PMCPMC13488093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.