Evidence map›Paper›PMID 42621904›Full record

ArticleACS medicinal chemistry letters2026

Bicyclo[1.1.1]pentane as a Phenyl Isosteric Replacement.

Anastasia Saar, David C Kombo, Sukanthini Thurairatnam, Michael Kothe, Gregory Merriman, Artem V Tsymbal, John L Kane, Matthew J LaMarche, Paraskevi Gkeka, Yi Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anastasia SaarIntegrated Drug Discovery, Sanofi, 350 Water St., Cambridge, Massachusetts 02141, United States.ORCID https://orcid.org/0009-0004-2961-5073
David C KomboIntegrated Drug Discovery, Sanofi, 350 Water St., Cambridge, Massachusetts 02141, United States.ORCID https://orcid.org/0009-0002-7746-0358
Sukanthini ThurairatnamIntegrated Drug Discovery, Sanofi, 350 Water St., Cambridge, Massachusetts 02141, United States.ORCID https://orcid.org/0000-0002-5106-8393
Michael KotheIntegrated Drug Discovery, Sanofi, 350 Water St., Cambridge, Massachusetts 02141, United States.
Gregory MerrimanIntegrated Drug Discovery, Sanofi, 350 Water St., Cambridge, Massachusetts 02141, United States.
Artem V TsymbalIntegrated Drug Discovery, Sanofi, 350 Water St., Cambridge, Massachusetts 02141, United States.ORCID https://orcid.org/0000-0001-5077-1928
John L KaneIntegrated Drug Discovery, Sanofi, 350 Water St., Cambridge, Massachusetts 02141, United States.ORCID https://orcid.org/0009-0006-6971-6797
Matthew J LaMarcheIntegrated Drug Discovery, Sanofi, 350 Water St., Cambridge, Massachusetts 02141, United States.ORCID https://orcid.org/0000-0002-6588-2302
Paraskevi GkekaIntegrated Drug Discovery, Sanofi, Impasse des Ateliers, Vitry-sur-Seine 94400, France.ORCID https://orcid.org/0000-0002-0752-3539
Yi LiIntegrated Drug Discovery, Sanofi, 350 Water St., Cambridge, Massachusetts 02141, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In medicinal chemistry, phenyl rings are often replaced with bioisosteres to optimize druglike properties. Bicyclo[1.1.1]-pentane (BCP) is a widely used sp

Indexed as

ADMEbicyclo[1.1.1]pentanebioisosterelipophilic efficiencymatched molecular pairsphenyl

Identifiers

PMID42621904
PMCPMC13488104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.