Evidence map›Paper›PMID 42621902›Full record

ArticleBlood vessels, thrombosis & hemostasis2026

Doxycycline for epistaxis in hereditary hemorrhagic telangiectasia: genotype-stratified outcomes.

Jinelis Santiago-Beniquez, Avraham Adelman, Eunice Im, Anil Patel, Nikita Chapurin, Christina Eagan, Ali Ataya, Marc Zumberg, Jennifer K Mulligan, Carl Atkinson and 2 more

Abstract read
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In one paragraph

Article in Blood vessels, thrombosis & hemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jinelis Santiago-BeniquezDivision of Rhinology & Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, University of Florida, Gainesville, FL.
Avraham AdelmanDivision of Rhinology & Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, University of Florida, Gainesville, FL.
Eunice ImDivision of Rhinology & Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, University of Florida, Gainesville, FL.
Anil PatelDivision of Rhinology & Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, University of Florida, Gainesville, FL.
Nikita ChapurinDivision of Rhinology & Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, University of Florida, Gainesville, FL.
Christina EaganDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL.
Ali AtayaDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL.
Marc ZumbergDivision of Hematology & Oncology, Department of Medicine, University of Florida, Gainesville, FL.
Jennifer K MulliganDivision of Rhinology & Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, University of Florida, Gainesville, FL.
Carl AtkinsonDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Evanston, IL.
Brian C LoboDivision of Rhinology & Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, University of Florida, Gainesville, FL.
Jeb M JusticeDivision of Rhinology & Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, University of Florida, Gainesville, FL.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with hereditary hemorrhagic telangiectasia (HHT) experience recurrent epistaxis. Doxycycline has been proposed as a possible treatment, although its efficacy remains controversial. Whether the most common genotypes (activin receptor-like kinase 1, endoglin, and SMAD4) contribute to a differential response has not been investigated. In this study, we evaluate the effectiveness of doxycycline among the different HHT genotypes. A retrospective cohort study was conducted at the University of Florida's Hereditary Hemorrhagic Telangiectasia Center. Forty-one adult patients (aged ≥18 years) with HHT, diagnosed by Curacao criteria and genetic testing, were classified as responders and nonresponders based on the minimal clinically important change between pre- and posttreatment epistaxis severity scores (ESS). Hemoglobin and hematocrit values were also collected to assess treatment response. Overall, the cohort was 61% female and 90.2% White, with a mean age of 58.1 years; 26 responders had a decrease (

Identifiers

PMID42621902
PMCPMC13488059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.