ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Toward Personalized Theranostics: A Modular PET Platform for Antibody-Based Imaging and Therapy.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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17 authors.
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Abstract
The expansion of personalized medicine is encouraging the development of platforms capable of supporting individualized imaging and therapeutic strategies. The combination of antibodies, with their intrinsic selectivity, and a modular molecular probe provides a strong foundation for such approaches. In this context, a versatile platform enabling positron emission tomography (PET) imaging followed by copper-free click-based functionalization is developed. A DFO-Lysine-DBCO probe is synthesized and site-specifically coupled to trastuzumab, allowing the introduction of diverse payloads, including β- or α-emitter chelators, a fluorophore, and a cytotoxic agent. Within this toolbox, the DFO/DOTAGA bischelate is selected for detailed evaluation. Radiolabeling confirms the selectivity of DFO and DOTAGA for
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