Evidence map›Paper›PMID 42621674›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Decoy-Receptor-Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration.

Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fudong LiDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-3407-0715
Bin ZhangDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-2067-2061
Zhiqiu ZhangDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0009-0002-3117-5009
Bing ZhengDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-9659-1276
Linhui HanDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0009-0007-5836-8886
Chen YanDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-9062-4735
Jialin LiDepartment of Orthopedics, Naval Medical Center of PLA, Navy Medical University, Shanghai, China.ORCID https://orcid.org/0000-0001-5880-9548
Kaiqiang SunDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-0272-8383
Tianyi ZhaoDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0009-0009-8469-5797
Jiangang ShiDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0003-2133-0108

Funding

General Program of the China Postdoctoral Science Foundation 2025M784490National Natural Science Foundation of China 82302760National Natural Science Foundation of China 82472493Qihang talent project of Naval Medical University 2025TPSL0009University-level Project of Naval Medical University 2022MS033
6 · The paper itself

Abstract

Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared inflammatory pathologies, yet lack effective disease-modifying therapies. Pro-inflammatory macrophages are central to their pathogenesis, but their selective therapeutic modulation remains a major challenge. Here, we first used single-cell transcriptomics to identify a conserved, pathogenic interleukin-1β (IL-1β)

Indexed as

intervertebral disc degenerationmacrophagemacrophage‐biomimetic nanosystemNF‐κB pathwayNLRP3osteoarthritispyroptosis

Identifiers

PMID42621674
PMCPMC13491363

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.